Erik Renstrom
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Explore the profile of Erik Renstrom including associated specialties, affiliations and a list of published articles.
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81
Citations
3384
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Recent Articles
1.
Lindqvist A, Abels M, Shcherbina L, Ngara M, Kryvokhyzha D, Chriett S, et al.
iScience
. 2023 Dec;
26(12):108416.
PMID: 38077141
Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for...
2.
Guo Q, AlKendi A, Jiang X, Mittone A, Wang L, Larsson E, et al.
Heliyon
. 2023 Jan;
9(2):e13081.
PMID: 36718155
The pancreatic islet is a highly structured micro-organ that produces insulin in response to rising blood glucose. Here we develop a label-free and automatic imaging approach to visualize the islets...
3.
Barghouth M, Ye Y, Karagiannopoulos A, Ma Y, Cowan E, Wu R, et al.
Cell Calcium
. 2022 Nov;
108:102669.
PMID: 36347081
Voltage-gated Ca (Ca) channel dysfunction leads to impaired glucose-stimulated insulin secretion in pancreatic β-cells and contributes to the development of type-2 diabetes (T2D). The role of the low-voltage gated T-type...
4.
Asplund O, Storm P, Chandra V, Hatem G, Ottosson-Laakso E, Mansour-Aly D, et al.
Life Sci Alliance
. 2022 Aug;
5(12).
PMID: 35948367
Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide...
5.
Ye Y, Barghouth M, Dou H, Luan C, Wang Y, Karagiannopoulos A, et al.
Nat Commun
. 2022 Jul;
13(1):4237.
PMID: 35869052
Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (K) channels is a key event in this process. However, K channel closure alone is not sufficient to...
6.
Golec E, Ekstrom A, Noga M, Omar-Hmeadi M, Lund P, Villoutreix B, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2120083119.
PMID: 35666870
Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so...
7.
Wu R, Karagiannopoulos A, Eliasson L, Renstrom E, Luan C, Zhang E
Biomedicines
. 2022 Apr;
10(4).
PMID: 35453520
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is...
8.
Cataldo L, Singh T, Achanta K, Bsharat S, Prasad R, Luan C, et al.
Acta Physiol (Oxf)
. 2022 Jan;
234(2):e13761.
PMID: 34978761
Aims: Reduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors...
9.
Bompada P, Goncalves I, Wu C, Gao R, Sun J, Mir B, et al.
Biomedicines
. 2021 Dec;
9(12).
PMID: 34944721
There is emerging evidence of an association between epigenetic modifications, glycemic control and atherosclerosis risk. In this study, we mapped genome-wide epigenetic changes in patients with type 2 diabetes (T2D)...
10.
Wu C, Borne Y, Gao R, Lopez Rodriguez M, Roell W, Wilson J, et al.
Nat Commun
. 2021 Nov;
12(1):6486.
PMID: 34759311
The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and...