Erik M Quandt
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Explore the profile of Erik M Quandt including associated specialties, affiliations and a list of published articles.
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11
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264
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Recent Articles
1.
Ochman H, Quandt E, Gottell N, Gilbert J
Sustain Microbiol
. 2024 Feb;
1(1):qvad003.
PMID: 38317688
Microbial communities serve as reservoirs of antibiotic resistance genes (ARGs) and facilitate the dissemination of these genes to bacteria that infect humans. Relatively little is known about the taxonomic distribution...
2.
Leon D, Dalton S, Quandt E, Barrick J
PLoS Genet
. 2018 Apr;
14(4):e1007348.
PMID: 29649242
Key innovations are disruptive evolutionary events that enable a species to escape constraints and rapidly diversify. After 15 years of the Lenski long-term evolution experiment with Escherichia coli, cells in...
3.
Quandt E, Traverse C, Ochman H
PeerJ
. 2018 Jan;
6:e4286.
PMID: 29362699
The maintenance of a G + C content that is higher than the mutational input to a genome provides support for the view that selection serves to increase G +...
4.
Quandt E, Gollihar J, Blount Z, Ellington A, Georgiou G, Barrick J
Elife
. 2015 Oct;
4.
PMID: 26465114
Evolutionary innovations that enable organisms to colonize new ecological niches are rare compared to gradual evolutionary changes in existing traits. We discovered that key mutations in the gltA gene, which...
5.
Quandt E, Summers R, Subramanian M, Barrick J
Genome Announc
. 2015 Jun;
3(3).
PMID: 26067973
Pseudomonas putida CBB5 was isolated from soil by enriching for growth on caffeine (1,3,7-trimethylxanthine). The draft genome of this strain is 6.9 Mb, with 5,941 predicted coding sequences. It includes...
6.
Chrysostomou C, Quandt E, Marshall N, Stone E, Georgiou G
ACS Chem Biol
. 2014 Dec;
10(3):875-82.
PMID: 25517993
Microbial arsenate resistance is known to be conferred by specialized oxidoreductase enzymes termed arsenate reductases. We carried out a genetic selection on media supplemented with sodium arsenate for multicopy genes...
7.
Quandt E, Deatherage D, Ellington A, Georgiou G, Barrick J
Proc Natl Acad Sci U S A
. 2014 Jan;
111(6):2217-22.
PMID: 24379390
Evolutionary innovations often arise from complex genetic and ecological interactions, which can make it challenging to understand retrospectively how a novel trait arose. In a long-term experiment, Escherichia coli gained...
8.
Enyeart P, Chirieleison S, Dao M, Perutka J, Quandt E, Yao J, et al.
Mol Syst Biol
. 2013 Sep;
9:685.
PMID: 24002656
Efficient bacterial genetic engineering approaches with broad-host applicability are rare. We combine two systems, mobile group II introns ('targetrons') and Cre/lox, which function efficiently in many different organisms, into a...
9.
Summers R, Seffernick J, Quandt E, Yu C, Barrick J, Subramanian M
J Bacteriol
. 2013 Jul;
195(17):3933-9.
PMID: 23813729
Caffeine and other N-methylated xanthines are natural products found in many foods, beverages, and pharmaceuticals. Therefore, it is not surprising that bacteria have evolved to live on caffeine as a...
10.
Quandt E, Hammerling M, Summers R, Otoupal P, Slater B, Alnahhas R, et al.
ACS Synth Biol
. 2013 May;
2(6):301-7.
PMID: 23654268
The widespread use of caffeine (1,3,7-trimethylxanthine) and other methylxanthines in beverages and pharmaceuticals has led to significant environmental pollution. We have developed a portable caffeine degradation operon by refactoring the...