Everett Stone
Overview
Explore the profile of Everett Stone including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2893
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0
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Recent Articles
1.
Gjuka D, Adib E, Garrison K, Chen J, Zhang Y, Li W, et al.
Cancer Cell
. 2023 Sep;
41(10):1774-1787.e9.
PMID: 37774699
Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in cancer. 9p21 loss is correlated with reduced tumor-infiltrating lymphocytes (TILs)...
2.
Wilder C, Chiou J, Battenhouse A, Saha A, Chen Z, Kim E, et al.
Mol Carcinog
. 2023 Jun;
62(10):1531-1545.
PMID: 37378415
Many cancers, including melanoma, have a higher requirement for l-methionine in comparison with noncancerous cells. In this study, we show that administration of an engineered human methionine-γ-lyase (hMGL) significantly reduced...
3.
Saha A, Zhao S, Kindall A, Wilder C, Friedman C, Clark R, et al.
J Exp Clin Cancer Res
. 2023 May;
42(1):119.
PMID: 37170264
Background: Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality. Therapy resistance and significant side effects of current...
4.
Blazeck J, Karamitros C, Ford K, Somody C, Qerqez A, Murray K, et al.
Nat Catal
. 2022 Dec;
5(10):952-967.
PMID: 36465553
The Trp metabolite kynurenine (KYN) accumulates in numerous solid tumours and mediates potent immunosuppression. Bacterial kynureninases (KYNases), which preferentially degrade kynurenine, can relieve immunosuppression in multiple cancer models, but immunogenicity...
5.
Zhang L, Hobeika C, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2122840119.
PMID: 35867762
Chromophobe (Ch) renal cell carcinoma (RCC) arises from the intercalated cell in the distal nephron. There are no proven treatments for metastatic ChRCC. A distinguishing characteristic of ChRCC is strikingly...
6.
Pataskar A, Champagne J, Nagel R, Kenski J, Laos M, Michaux J, et al.
Nature
. 2022 Jul;
608(7922):E20.
PMID: 35840685
No abstract available.
7.
Pataskar A, Champagne J, Nagel R, Kenski J, Laos M, Michaux J, et al.
Nature
. 2022 Mar;
603(7902):721-727.
PMID: 35264796
Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across...
8.
Kang Y, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, et al.
Cell Metab
. 2020 Dec;
33(1):174-189.e7.
PMID: 33357455
Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic...
9.
Saha A, Zhao S, Chen Z, Georgiou G, Stone E, Kidane D, et al.
Mol Ther
. 2020 Oct;
29(2):775-787.
PMID: 33091613
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest forms of cancer with very few available therapeutic options. We previously reported that an engineered human enzyme, cyst(e)inase, which degrades L-cysteine...
10.
Lu W, Saha A, Yan W, Garrison K, Lamb C, Pandey R, et al.
Proc Natl Acad Sci U S A
. 2020 May;
117(23):13000-13011.
PMID: 32434918
Extensive studies in prostate cancer and other malignancies have revealed that l-methionine (l-Met) and its metabolites play a critical role in tumorigenesis. Preclinical and clinical studies have demonstrated that systemic...