Erik J Coffman
Overview
Explore the profile of Erik J Coffman including associated specialties, affiliations and a list of published articles.
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6
Citations
607
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Recent Articles
1.
Kim W, Rivera M, Coffman E, Haber D
Mol Cell
. 2012 Jan;
45(5):587-97.
PMID: 22285752
WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in β-catenin turnover, but its effect on nuclear proteins...
2.
Faber A, Corcoran R, Ebi H, Sequist L, Waltman B, Chung E, et al.
Cancer Discov
. 2011 Dec;
1(4):352-65.
PMID: 22145099
Cancers with specific genetic mutations are susceptible to selective kinase inhibitors. However, there is a wide spectrum of benefit among cancers harboring the same sensitizing genetic mutations. Herein, we measured...
3.
Moisan A, Rivera M, Lotinun S, Akhavanfard S, Coffman E, Cook E, et al.
Dev Cell
. 2011 May;
20(5):583-596.
PMID: 21571217
WTX is an X-linked tumor suppressor targeted by somatic mutations in Wilms tumor, a pediatric kidney cancer, and by germline inactivation in osteopathia striata with cranial sclerosis, a bone overgrowth...
4.
Ting D, Lipson D, Paul S, Brannigan B, Akhavanfard S, Coffman E, et al.
Science
. 2011 Jan;
331(6017):593-6.
PMID: 21233348
Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these...
5.
Presser Aiden A, Rivera M, Rheinbay E, Ku M, Coffman E, Truong T, et al.
Cell Stem Cell
. 2010 Jun;
6(6):591-602.
PMID: 20569696
Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells...
6.
Rivera M, Kim W, Wells J, Stone A, Burger A, Coffman E, et al.
Proc Natl Acad Sci U S A
. 2009 May;
106(20):8338-43.
PMID: 19416806
WTX encodes a tumor suppressor gene inactivated in Wilms tumor and recently implicated in WNT signaling through enhancement of cytoplasmic beta-catenin (CTNNB1) degradation. Here, we report that WTX translocates to...