Erik I Christensen
Overview
Explore the profile of Erik I Christensen including associated specialties, affiliations and a list of published articles.
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84
Citations
2371
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Recent Articles
1.
Skeby C, Hummelgaard S, Gustafsen C, Petrillo F, Frederiksen K, Olsen D, et al.
Kidney Int
. 2023 Jul;
104(4):754-768.
PMID: 37406929
Proteinuria is a prominent feature of chronic kidney disease. Interventions that reduce proteinuria slow the progression of chronic kidney disease and the associated risk of cardiovascular disease. Here, we propose...
2.
Rinschen M, Harder J, Carter-Timofte M, Zanon Rodriguez L, Mirabelli C, Demir F, et al.
Sci Signal
. 2022 Nov;
15(762):eabo7940.
PMID: 36445937
The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls...
3.
Edwards A, Christensen E, Unwin R, Norden A
Kidney Int Rep
. 2021 Mar;
6(3):867.
PMID: 33733005
No abstract available.
4.
Christensen E, Kristoffersen I, Grann B, Thomsen J, Andreasen A, Nielsen R
Kidney Int
. 2020 Dec;
99(4):841-853.
PMID: 33340516
Proteinuria is a well-established marker and predictor of kidney disease. The receptors megalin and cubilin reabsorb filtered proteins and thereby proteinuria is avoided. It is unknown if all segments of...
5.
Edwards A, Christensen E, Unwin R, Norden A
J Physiol
. 2020 Oct;
599(1):323-341.
PMID: 33107589
Key Points: The presence of plasma proteins in urine is difficult to interpret quantitatively. It may be a result of impaired glomerular filtration or impaired proximal tubule (PT) reabsorption, or...
6.
Ren Q, Weyer K, Rbaibi Y, Long K, Tan R, Nielsen R, et al.
Am J Physiol Renal Physiol
. 2020 Mar;
318(5):F1284-F1294.
PMID: 32200668
Proximal tubule (PT) cells express a single saturable albumin-binding site whose affinity matches the estimated tubular concentration of albumin; however, albumin uptake capacity is greatly increased under nephrotic conditions. Deciphering...
7.
Janssens V, Gaide Chevronnay H, Marie S, Vincent M, Van Der Smissen P, Nevo N, et al.
J Am Soc Nephrol
. 2019 Sep;
30(11):2177-2190.
PMID: 31548351
Background: Deletions or inactivating mutations of the cystinosin gene lead to cystine accumulation and crystals at acidic pH in patients with nephropathic cystinosis, a rare lysosomal storage disease and the...
8.
Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth C, et al.
J Biol Chem
. 2019 May;
294(21):8349.
PMID: 31127061
No abstract available.
9.
Storm T, Burgoyne T, Dunaief J, Christensen E, Futter C, Nielsen R
Invest Ophthalmol Vis Sci
. 2019 Jan;
60(1):322-330.
PMID: 30665232
Purpose: Mutations in the megalin-encoding gene, LRP2, cause high myopia as seen in patients suffering from Donnai-Barrow/facio-oculo-acoustico-renal syndrome. Megalin is present in both the nonpigmented epithelium of the ciliary body...
10.
Tokonami N, Takata T, Beyeler J, Ehrbar I, Yoshifuji A, Christensen E, et al.
Kidney Int
. 2018 Jul;
94(4):701-715.
PMID: 30007527
Uromodulin, the most abundant protein in normal urine, is essentially produced by the cells lining the thick ascending limb. There it regulates the activity of the cotransporter NKCC2 and is...