Erik B Malarkey
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Explore the profile of Erik B Malarkey including associated specialties, affiliations and a list of published articles.
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26
Citations
1063
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Recent Articles
1.
Lewis W, Bales K, Revell D, Croyle M, Engle S, Song C, et al.
FASEB J
. 2018 Aug;
33(1):1440-1455.
PMID: 30133325
The transition zone (TZ) is a domain at the base of the cilium that is involved in maintaining ciliary compartment-specific sensory and signaling activity by regulating cilia protein composition. Mutations...
2.
Lewis W, Malarkey E, Tritschler D, Bower R, Pasek R, Porath J, et al.
PLoS Genet
. 2016 Jul;
12(7):e1006220.
PMID: 27472056
Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or 'primary' cilia having a 9+0...
3.
Masyukova S, Landis D, Henke S, Williams C, Pieczynski J, Roszczynialski K, et al.
PLoS Genet
. 2016 Feb;
12(2):e1005841.
PMID: 26863025
Nephronophthisis (NPHP) is a ciliopathy in which genetic modifiers may underlie the variable penetrance of clinical features. To identify modifiers, a screen was conducted on C. elegans nphp-4(tm925) mutants. Mutations...
4.
Sanders A, de Vrieze E, AlAzami A, Alzahrani F, Malarkey E, Sorusch N, et al.
Genome Biol
. 2015 Dec;
16:293.
PMID: 26714646
Background: Joubert syndrome (JBTS) and related disorders are defined by cerebellar malformation (molar tooth sign), together with neurological symptoms of variable expressivity. The ciliary basis of Joubert syndrome related disorders...
5.
Cavender C, Gottipati M, Malarkey E, Parpura V
Inquiro
. 2014 Dec;
7:48-52.
PMID: 25544968
Astrocytes provide a principal pathway for glutamate uptake in the mammalian brain, a task accomplished by the powerful action of excitatory amino acid transporters (EAAT) 1 and 2. These transporters...
6.
Berbari N, Malarkey E, Yazdi S, McNair A, Kippe J, Croyle M, et al.
PLoS One
. 2014 Sep;
9(9):e106576.
PMID: 25184295
It has been known for decades that neurons throughout the brain possess solitary, immotile, microtubule based appendages called primary cilia. Only recently have studies tried to address the functions of...
7.
OConnor A, Malarkey E, Berbari N, Croyle M, Haycraft C, Bell P, et al.
Cilia
. 2013 Jul;
2(1):8.
PMID: 23819925
Background: Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and...
8.
Berbari N, Pasek R, Malarkey E, Yazdi S, McNair A, Lewis W, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(19):7796-801.
PMID: 23599282
Although primary cilia are well established as important sensory and signaling structures, their function in most tissues remains unknown. Obesity is a feature associated with some syndromes of cilia dysfunction,...
9.
Sharma N, Malarkey E, Berbari N, OConnor A, Vanden Heuvel G, Mrug M, et al.
J Am Soc Nephrol
. 2013 Feb;
24(3):456-64.
PMID: 23411784
Disrupting the function of cilia in mouse kidneys results in rapid or slow progression of cystic disease depending on whether the animals are juveniles or adults, respectively. Renal injury can...
10.
Berbari N, Sharma N, Malarkey E, Pieczynski J, Boddu R, Gaertig J, et al.
Cytoskeleton (Hoboken)
. 2012 Nov;
70(1):24-31.
PMID: 23124988
Disruption of the primary cilium is associated with a growing number of human diseases collectively termed ciliopathies. Ciliopathies present with a broad range of clinical features consistent with the near...