Erik A Toso
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Explore the profile of Erik A Toso including associated specialties, affiliations and a list of published articles.
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17
Citations
318
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Recent Articles
1.
Bedada F, Thompson B, Mikkila J, Chan S, Choi S, Toso E, et al.
Sci Rep
. 2024 Feb;
14(1):3915.
PMID: 38365813
Human induced pluripotent stem cells and their differentiation into cardiac myocytes (hiPSC-CMs) provides a unique and valuable platform for studies of cardiac muscle structure-function. This includes studies centered on disease...
2.
Schneider C, Leung J, Valenzuela-Leon P, Golviznina N, Toso E, Bosnakovski D, et al.
Nat Commun
. 2024 Feb;
15(1):1121.
PMID: 38321047
The first step in disease pathogenesis for arboviruses is the establishment of infection following vector transmission. For La Crosse virus (LACV), the leading cause of pediatric arboviral encephalitis in North...
3.
Bosnakovski D, Toso E, Ener E, Gearhart M, Yin L, Luttmann F, et al.
iScience
. 2023 Sep;
26(10):107823.
PMID: 37744032
Double homeobox (DUX) genes are unique to eutherian mammals, expressed transiently during zygotic genome activation (ZGA) and involved in facioscapulohumeral muscular dystrophy (FSHD) and cancer when misexpressed. We evaluate the...
4.
Bosnakovski D, Toso E, Ener E, Gearhart M, Yin L, Luttmann F, et al.
bioRxiv
. 2023 Jan;
PMID: 36711898
Highlights: Platypus sDUX is toxic and inhibits myogenic differentiation.DUXA targets overlap substantially with those of DUX4.DUXA fused to a synthetic transactivation domain acquires DUX4-like toxicity.DUXA behaves as a competitive inhibitor...
5.
Soliman H, Toso E, Darwish I, Ali S, Kyba M
Cell Death Dis
. 2022 Apr;
13(4):405.
PMID: 35468884
Inappropriate expression of DUX4, a transcription factor that induces cell death at high levels of expression and impairs myoblast differentiation at low levels of expression, leads to the development of...
6.
Bosnakovski D, Ener E, Cooper M, Gearhart M, Knights K, Xu N, et al.
Oncogenesis
. 2021 Oct;
10(10):68.
PMID: 34642317
CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the transcriptional repressor Capicua (CIC) fused to the...
7.
Corti S, Bonjean R, Legier T, Rattier D, Melon C, Salin P, et al.
Stem Cells Transl Med
. 2021 Feb;
10(5):725-742.
PMID: 33528918
Enhancing the differentiation potential of human induced pluripotent stem cells (hiPSC) into disease-relevant cell types is instrumental for their widespread application in medicine. Here, we show that hiPSCs downregulated for...
8.
Bosnakovski D, da Silva M, Sunny S, Ener E, Toso E, Yuan C, et al.
Sci Adv
. 2019 Sep;
5(9):eaaw7781.
PMID: 31535023
Facioscapulohumeral muscular dystrophy (FSHD) results from mutations causing overexpression of the transcription factor, DUX4, which interacts with the histone acetyltransferases, EP300 and CBP. We describe the activity of a new...
9.
Lee J, Bosnakovski D, Toso E, Dinh T, Banerjee S, Bohl T, et al.
Cell Rep
. 2018 Dec;
25(11):2955-2962.e3.
PMID: 30540931
Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations...
10.
Bosnakovski D, Gearhart M, Toso E, Ener E, Choi S, Kyba M
Sci Rep
. 2018 Nov;
8(1):16957.
PMID: 30446688
Loss of silencing of the DUX4 gene on chromosome 4 causes facioscapulohumeral muscular dystrophy. While high level DUX4 expression induces apoptosis, the effects of low level DUX4 expression on human...