Micah D Gearhart
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Explore the profile of Micah D Gearhart including associated specialties, affiliations and a list of published articles.
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52
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1352
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Recent Articles
1.
Rollman T, Berkebile Z, Okae H, Bardwell V, Gearhart M, Bierle C
J Virol
. 2024 Mar;
98(4):e0193523.
PMID: 38451085
Importance: Placental infection plays a central role in human cytomegalovirus (HCMV) pathogenesis during pregnancy, but the species specificity of HCMV and the limited availability and lifespan of primary trophoblasts have...
2.
Sadowski D, Corcoran C, Abdi R, Zheng T, Okae H, Arima T, et al.
bioRxiv
. 2024 Feb;
PMID: 38352412
Early defects in placenta development are thought to underlie a range of adverse pregnancy conditions including miscarriage, fetal growth abnormalities, preeclampsia, and stillbirth. Differentiating trophoblast stem cells undergo a choreographed...
3.
Pappas M, Kawakami H, Corcoran D, Chen K, Scott E, Wong J, et al.
Development
. 2024 Feb;
151(5).
PMID: 38345319
The trunk axial skeleton develops from paraxial mesoderm cells. Our recent study demonstrated that conditional knockout of the stem cell factor Sall4 in mice by TCre caused tail truncation and...
4.
Rollman T, Berkebile Z, Okae H, Bardwell V, Gearhart M, Bierle C
bioRxiv
. 2024 Jan;
PMID: 38168202
Importance: Placental infection plays a central role in HCMV pathogenesis during pregnancy, but the species-specificity of HCMV and the limited availability and lifespan of primary trophoblasts have been persistent barriers...
5.
Bosnakovski D, Toso E, Ener E, Gearhart M, Yin L, Luttmann F, et al.
iScience
. 2023 Sep;
26(10):107823.
PMID: 37744032
Double homeobox (DUX) genes are unique to eutherian mammals, expressed transiently during zygotic genome activation (ZGA) and involved in facioscapulohumeral muscular dystrophy (FSHD) and cancer when misexpressed. We evaluate the...
6.
Nashif S, Mahr R, Jena S, Jo S, Nelson A, Sadowski D, et al.
Front Cell Dev Biol
. 2023 May;
11:1167097.
PMID: 37250894
Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of...
7.
Mahr R, Jena S, Nashif S, Nelson A, Rauckhorst A, Rome F, et al.
Sci Rep
. 2023 May;
13(1):7387.
PMID: 37149697
Cytotrophoblasts fuse to form and renew syncytiotrophoblasts necessary to maintain placental health throughout gestation. During cytotrophoblast to syncytiotrophoblast differentiation, cells undergo regulated metabolic and transcriptional reprogramming. Mitochondria play a critical...
8.
Nashif S, Mahr R, Jena S, Jo S, Nelson A, Sadowski D, et al.
bioRxiv
. 2023 Feb;
PMID: 36824783
Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing risks of fetal...
9.
Bosnakovski D, Toso E, Ener E, Gearhart M, Yin L, Luttmann F, et al.
bioRxiv
. 2023 Jan;
PMID: 36711898
Highlights: Platypus sDUX is toxic and inhibits myogenic differentiation.DUXA targets overlap substantially with those of DUX4.DUXA fused to a synthetic transactivation domain acquires DUX4-like toxicity.DUXA behaves as a competitive inhibitor...
10.
Mahr R, Jena S, Nashif S, Nelson A, Rauckhorst A, Rome F, et al.
bioRxiv
. 2023 Jan;
PMID: 36711862
Cytotrophoblasts fuse to form and renew syncytiotrophoblasts necessary to maintain placental health throughout gestation. During cytotrophoblast to syncytiotrophoblast differentiation, cells undergo regulated metabolic and transcriptional reprogramming. Mitochondria play a critical...