Eric W Roth
Overview
Explore the profile of Eric W Roth including associated specialties, affiliations and a list of published articles.
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31
Citations
688
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Recent Articles
1.
Wang-Bishop L, Wehbe M, Pastora L, Yang J, Kimmel B, Garland K, et al.
ACS Nano
. 2024 Apr;
18(18):11631-11643.
PMID: 38652829
Pharmacological activation of the retinoic acid-inducible gene I (RIG-I) pathway holds promise for increasing tumor immunogenicity and improving the response to immune checkpoint inhibitors (ICIs). However, the potency and clinical...
2.
Baljon J, Kwiatkowski A, Pagendarm H, Stone P, Kumar A, Bharti V, et al.
ACS Nano
. 2024 Feb;
18(9):6845-6862.
PMID: 38386282
Immune checkpoint blockade (ICB) has revolutionized cancer treatment and led to complete and durable responses, but only for a minority of patients. Resistance to ICB can largely be attributed to...
3.
Engineering endosomolytic nanocarriers of diverse morphologies using confined impingement jet mixing
Pagendarm H, Stone P, Kimmel B, Baljon J, Aziz M, Pastora L, et al.
Nanoscale
. 2023 Sep;
15(39):16016-16029.
PMID: 37753868
The clinical translation of many biomolecular therapeutics has been hindered by undesirable pharmacokinetic (PK) properties, inadequate membrane permeability, poor endosomal escape and cytosolic delivery, and/or susceptibility to degradation. Overcoming these...
4.
Waltmann C, Kennedy N, Mills C, Roth E, Ikonomova S, Tullman-Ercek D, et al.
ACS Nano
. 2023 Aug;
17(16):15751-15762.
PMID: 37552700
An important goal of systems and synthetic biology is to produce high value chemical species in large quantities. Microcompartments, which are protein nanoshells encapsulating catalytic enzyme cargo, could potentially function...
5.
De Mel J, Hossain M, Shofolawe-Bakare O, Mohammad S, Rasmussen E, Milloy K, et al.
Mol Pharm
. 2022 Nov;
19(12):4705-4716.
PMID: 36374992
Traditional approaches to vaccines use whole organisms to trigger an immune response, but they do not typically generate robust cellular-mediated immunity and have various safety risks. Subunit vaccines composed of...
6.
Lin Y, Gao X, Yue J, Fang Y, Shi J, Meng L, et al.
Nat Chem
. 2022 Oct;
15(1):119-128.
PMID: 36280766
Interactions between the microbiota and their colonized environments mediate critical pathways from biogeochemical cycles to homeostasis in human health. Here we report a soil-inspired chemical system that consists of nanostructured...
7.
Shofolawe-Bakare O, De Mel J, Mishra S, Hossain M, Hamadani C, Pride M, et al.
Macromol Biosci
. 2022 Sep;
22(12):e2200281.
PMID: 36125638
Macrophages play a diverse, key role in many pathologies, including inflammatory diseases, cardiovascular diseases, and cancer. However, many therapeutic strategies targeting macrophages suffer from systemic off-target toxicity resulting in notoriously...
8.
McCourt J, Kewalramani S, Gao C, Roth E, Weigand S, Olvera de la Cruz M, et al.
ACS Cent Sci
. 2022 Aug;
8(8):1169-1181.
PMID: 36032772
How molecular chirality manifests at the nano- to macroscale has been a scientific puzzle since Louis Pasteur discovered biochirality. Chiral molecules assemble into meso-shapes such as twisted and helical ribbons,...
9.
Mills C, Waltmann C, Archer A, Kennedy N, Abrahamson C, Jackson A, et al.
Nat Commun
. 2022 Jun;
13(1):3746.
PMID: 35768404
Engineering subcellular organization in microbes shows great promise in addressing bottlenecks in metabolic engineering efforts; however, rules guiding selection of an organization strategy or platform are lacking. Here, we study...
10.
Vu T, Peruzzi J, SantAnna L, Roth E, Kamat N
Nano Lett
. 2022 Mar;
22(7):2627-2634.
PMID: 35298184
Ligand spatial presentation and density play important roles in signaling pathways mediated by cell receptors and are critical parameters when designing protein-conjugated therapeutic nanoparticles. Here, we harness lipid phase separation...