Eric W Ottesen
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Explore the profile of Eric W Ottesen including associated specialties, affiliations and a list of published articles.
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22
Citations
745
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Recent Articles
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Ottesen E, Singh N, Seo J, Singh R
Front Neurosci
. 2024 Aug;
18():1412893.
PMID: 39086841
Introduction: The U1 small nuclear RNA (snRNA) forms ribonucleoprotein particles (RNPs) such as U1 snRNP and U1-TAF15 snRNP. U1 snRNP is one of the most studied RNPs due to its...
3.
Luo D, Ottesen E, Lee J, Singh R
Sci Rep
. 2024 May;
14(1):10442.
PMID: 38714739
Spinal muscular atrophy (SMA) genes, SMN1 and SMN2 (hereinafter referred to as SMN1/2), produce multiple circular RNAs (circRNAs), including C2A-2B-3-4 that encompasses early exons 2A, 2B, 3 and 4. C2A-2B-3-4...
4.
Ottesen E, Singh R
Neurosci Insights
. 2024 Feb;
19():26331055241233596.
PMID: 38379891
Spinal muscular atrophy (SMA) is treated by increasing the level of Survival Motor Neuron (SMN) protein through correction of exon 7 skipping or exogenous expression of SMN through gene therapy....
5.
Ottesen E, Seo J, Luo D, Singh N, Singh R
Nucleic Acids Res
. 2024 Jan;
52(7):3547-3571.
PMID: 38214229
Here we report a Survival Motor Neuron 2 (SMN2) super minigene, SMN2Sup, encompassing its own promoter, all exons, their flanking intronic sequences and the entire 3'-untranslated region. We confirm that...
6.
Ottesen E, Singh N, Luo D, Kaas B, Gillette B, Seo J, et al.
Nucleic Acids Res
. 2023 Apr;
51(12):5948-5980.
PMID: 37026480
Designing an RNA-interacting molecule that displays high therapeutic efficacy while retaining specificity within a broad concentration range remains a challenging task. Risdiplam is an FDA-approved small molecule for the treatment...
7.
Singh R, Ottesen E, Singh N
Neurosci Insights
. 2020 Dec;
15:2633105520973985.
PMID: 33283185
Spinal muscular atrophy (SMA) is 1 of the leading causes of infant mortality. SMA is mostly caused by low levels of Survival Motor Neuron (SMN) protein due to deletion of...
8.
Ottesen E, Singh R
Cell Signal
. 2020 Jun;
73:109696.
PMID: 32553550
Circular RNAs (circRNAs) belong to a diverse class of stable RNAs expressed in all cell types. Their proposed functions include sponging of microRNAs (miRNAs), sequestration and trafficking of proteins, assembly...
9.
Singh N, Ottesen E, Singh R
Biochim Biophys Acta Gene Regul Mech
. 2020 May;
1863(8):194562.
PMID: 32387331
Human Survival Motor Neuron (SMN) genes code for SMN, an essential multifunctional protein. Complete loss of SMN is embryonic lethal, while low levels of SMN lead to spinal muscular atrophy...
10.
Ottesen E, Luo D, Seo J, Singh N, Singh R
Nucleic Acids Res
. 2019 Jan;
47(6):2884-2905.
PMID: 30698797
Circular RNAs (circRNAs) perform diverse functions, including the regulation of transcription, translation, peptide synthesis, macromolecular sequestration and trafficking. Inverted Alu repeats capable of forming RNA:RNA duplexes that bring splice sites...