Eric S Diffenderfer
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Explore the profile of Eric S Diffenderfer including associated specialties, affiliations and a list of published articles.
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34
Citations
496
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Recent Articles
11.
Zou W, Zhang R, Schuler E, Taylor P, Mascia A, Diffenderfer E, et al.
Int J Radiat Oncol Biol Phys
. 2023 Apr;
116(5):1202-1217.
PMID: 37121362
FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR), may allow patients to be treated with less normal tissue toxicity for a given tumor dose compared with currently used...
12.
Zou W, Kim H, Diffenderfer E, Carlson D, Koch C, Xiao Y, et al.
Front Oncol
. 2022 Dec;
12:1004121.
PMID: 36518319
Introduction: Radiation-induced oxygen depletion in tissue is assumed as a contributor to the FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in the tissue surrounding the...
13.
Luna J, Barsky A, Shinohara R, Roshkovan L, Hershman M, Dreyfuss A, et al.
Cancers (Basel)
. 2022 Feb;
14(3).
PMID: 35158971
We evaluate radiomic phenotypes derived from CT scans as early predictors of overall survival (OS) after chemoradiation in stage III primary lung adenocarcinoma. We retrospectively analyzed 110 thoracic CT scans...
14.
Karakasheva T, Gabre J, Sachdeva U, Cruz-Acuna R, Lin E, DeMarshall M, et al.
Sci Rep
. 2021 Oct;
11(1):21304.
PMID: 34716381
3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical...
15.
Diffenderfer E, Sorensen B, Mazal A, Carlson D
Med Phys
. 2021 Oct;
49(3):2039-2054.
PMID: 34644403
We review the current status of proton FLASH experimental systems, including preclinical physical and biological results. Technological limitations on preclinical investigation of FLASH biological mechanisms and determination of clinically relevant...
16.
Kim M, Verginadis I, Goia D, Haertter A, Shoniyozov K, Zou W, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439398
Ultra-high dose rate FLASH proton radiotherapy (F-PRT) has been shown to reduce normal tissue toxicity compared to standard dose rate proton radiotherapy (S-PRT) in experiments using the entrance portion of...
17.
Zou W, Diffenderfer E, Ota K, Boisseau P, Kim M, Cai Y, et al.
Med Phys
. 2021 Apr;
48(7):3948-3957.
PMID: 33843065
Introduction: Ultra-high dose rate (FLASH) radiotherapy has become a popular research topic with the potential to reduce normal tissue toxicities without losing the benefit of tumor control. The development of...
18.
Zou W, Diffenderfer E, Cengel K, Kim M, Avery S, Konzer J, et al.
Radiother Oncol
. 2020 Nov;
155:212-218.
PMID: 33186682
Purpose: Proton Pencil Beam Scanning (PBS) is an attractive solution to realize the advantageous normal tissue sparing elucidated from FLASH high dose rates. The mechanics of PBS spot delivery will...
19.
Luna J, Chao H, Shinohara R, Ungar L, Cengel K, Pryma D, et al.
Clin Transl Radiat Oncol
. 2020 Apr;
22:69-75.
PMID: 32274426
Background And Purpose: Radiation esophagitis is a clinically important toxicity seen with treatment for locally-advanced non-small cell lung cancer. There is considerable disagreement among prior studies in identifying predictors of...
20.
Reply to Nock and Nielsen: On the work of Nock and Nielsen and its relationship to the additive tree
Valdes G, Luna J, Gennatas E, Ungar L, Eaton E, Diffenderfer E, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(16):8694-8695.
PMID: 32265277
No abstract available.