Eric M Woerly
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Explore the profile of Eric M Woerly including associated specialties, affiliations and a list of published articles.
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12
Citations
188
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Recent Articles
1.
Kielbasa W, Goldsmith P, Donnelly K, Nuthall H, Shcherbinin S, Fleisher A, et al.
Alzheimers Dement (N Y)
. 2025 Jan;
10(4):e70020.
PMID: 39748851
Introduction: The aggregation and spread of hyperphosphorylated, pathological tau in the human brain is hypothesized to play a key role in Alzheimer's disease (AD) as well as other neurogenerative tauopathies....
2.
Sloop K, Cox A, Wainscott D, White A, Droz B, Stutsman C, et al.
Sci Transl Med
. 2024 Dec;
16(778):eadp5765.
PMID: 39693407
Orally bioavailable, synthetic nonpeptide agonists (NPAs) of the glucagon-like peptide-1 receptor (GLP-1R) may offer an effective, scalable pharmacotherapy to address the metabolic disease epidemic. One of the first molecules in...
3.
Klootwyk B, Ruble J, Cumming G, Woerly E
J Org Chem
. 2024 Apr;
89(8):5901-5904.
PMID: 38567761
The Miyaura borylation of aryl and heteroaryl chlorides and bromides using a combination of potassium carbonate and 5 mol % 2-ethylhexanoic acid at 25 °C is reported. The generation of...
4.
Haley H, Hill A, Greenwood A, Woerly E, Rienstra C, Burke M
J Am Chem Soc
. 2018 Nov;
140(45):15227-15240.
PMID: 30388000
Antilipoperoxidant protein dysfunction is associated with many human diseases, suggesting that bilayer lipid peroxidation may contribute broadly to pathogenesis. Small molecule inhibitors of this membrane-localized chemistry could in theory enable...
5.
Woerly E, Banik S, Jacobsen E
J Am Chem Soc
. 2016 Oct;
138(42):13858-13861.
PMID: 27709922
The enantioselective synthesis of 4-fluoroisochromanones via chiral aryl iodide-catalyzed fluorolactonization is reported. This methodology uses HF-pyridine as a nucleophilic fluoride source with a peracid stoichiometric oxidant and provides access to...
6.
Woerly E, Roy J, Burke M
Nat Chem
. 2014 May;
6(6):484-91.
PMID: 24848233
The inherent modularity of polypeptides, oligonucleotides and oligosaccharides has been harnessed to achieve generalized synthesis platforms. Importantly, like these other targets, most small-molecule natural products are biosynthesized via iterative coupling...
7.
8.
Woerly E, Struble J, Palyam N, OHara S, Burke M
Tetrahedron
. 2012 Jul;
67(24):4333-4343.
PMID: 22753994
No abstract available.
9.
Dick G, Woerly E, Burke M
Angew Chem Int Ed Engl
. 2012 Jan;
51(11):2667-72.
PMID: 22287537
Problem solved: an air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery...
10.
Woerly E, Cherney A, Davis E, Burke M
J Am Chem Soc
. 2010 May;
132(20):6941-3.
PMID: 20441218
Stimulated by the substantial challenge of synthesizing the complex and sensitive stereogenic allene-containing core of (-)-peridinin, the first stereocontrolled coupling of haloallenes with boronic acids has been achieved. This new...