Eric M Phizicky
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Explore the profile of Eric M Phizicky including associated specialties, affiliations and a list of published articles.
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72
Citations
4356
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Recent Articles
1.
Stegemann F, Marcus E, Neupert S, Ostrowski S, Mathews D, Phizicky E
RNA
. 2025 Jan;
PMID: 39848696
The pseudouridylase Pus1 catalyzes pseudouridine (Ψ) formation at multiple uridine residues in tRNAs, and in some snRNAs and mRNAs. Although Pus1 is highly conserved, and mutations are associated with human...
2.
De Zoysa T, Hauke A, Iyer N, Marcus E, Ostrowski S, Stegemann F, et al.
PLoS Genet
. 2024 Jan;
20(1):e1011146.
PMID: 38295128
tRNA modifications are crucial in all organisms to ensure tRNA folding and stability, and accurate translation. In both the yeast Saccharomyces cerevisiae and the evolutionarily distant yeast Schizosaccharomyces pombe, mutants...
3.
De Zoysa T, Hauke A, Iyer N, Marcus E, Ostrowski S, Fay J, et al.
bioRxiv
. 2023 Oct;
PMID: 37790432
tRNA modifications are crucial in all organisms to ensure tRNA folding and stability, and accurate translation in the ribosome. In both the yeast and the evolutionarily distant yeast , mutants...
4.
Phizicky E, Hopper A
RNA
. 2023 Apr;
29(7):898-957.
PMID: 37055150
The study of eukaryotic tRNA processing has given rise to an explosion of new information and insights in the last several years. We now have unprecedented knowledge of each step...
5.
Tasak M, Phizicky E
PLoS Genet
. 2022 Jul;
18(7):e1010215.
PMID: 35901126
All tRNAs have numerous modifications, lack of which often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae, lack...
6.
Funk H, DiVita D, Sizemore H, Wehrle K, Miller C, Fraley M, et al.
ACS Omega
. 2022 May;
7(16):13667-13675.
PMID: 35559166
Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications are associated with numerous human disorders. Throughout eukaryotes, 2'--methylation of residues 32...
7.
Han L, Marcus E, Phizicky E
Methods Enzymol
. 2021 Sep;
658:359-377.
PMID: 34517954
A tRNA interacts with numerous proteins throughout its biogenesis and during translation, and a significant portion of these interacting proteins are involved in post-transcriptional modifications. While some of the modifying...
8.
De Zoysa T, Phizicky E
PLoS Genet
. 2020 Aug;
16(8):e1008893.
PMID: 32841241
All tRNAs are extensively modified, and modification deficiency often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae, lack...
9.
Payea M, Hauke A, De Zoysa T, Phizicky E
RNA
. 2019 Oct;
26(1):29-43.
PMID: 31619505
During tRNA maturation in yeast, aberrant pre-tRNAs are targeted for 3'-5' degradation by the nuclear surveillance pathway, and aberrant mature tRNAs are targeted for 5'-3' degradation by the rapid tRNA...
10.
Ramos J, Han L, Li Y, Hagelskamp F, Kellner S, Alkuraya F, et al.
Mol Cell Biol
. 2019 Jul;
39(19.
PMID: 31263000
The formation of inosine at the wobble position of eukaryotic tRNAs is an essential modification catalyzed by the ADAT2/ADAT3 complex. In humans, a valine-to-methionine mutation (V144M) in ADAT3 that originated...