Eric M Phillips
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Explore the profile of Eric M Phillips including associated specialties, affiliations and a list of published articles.
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26
Citations
309
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Recent Articles
11.
Molinaro C, Phillips E, Xiang B, Milczek E, Shevlin M, Balsells J, et al.
J Org Chem
. 2019 May;
84(12):8006-8018.
PMID: 31124362
A practical and efficient enantioselective synthesis of the calcitonin gene-related peptide receptor antagonist 1 has been developed. The key structural component of the active pharmaceutical ingredient is a syn-1,2-amino-fluoropiperidine 4....
12.
Smyth L, Phillips E, Chan V, Napolitano J, Henry R, Shekhar S
J Org Chem
. 2016 Jan;
81(3):1285-94.
PMID: 26735925
A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO2CF3 as the nucleophile is described. The combination of Pd2(dba)3 and RockPhos formed the most effective catalyst. A...
13.
Matsushima Y, Phillips E, Bergman R, Ellman J
Synlett
. 2015 Nov;
26(11):1533-1536.
PMID: 26609195
A new and unexpected Rh(I)-catalyzed cycloisomerization of 1,6-enynes is reported. Several different alkyne substitution patterns were evaluated under the reaction conditions, including a deuterated derivative that provides some insight into...
14.
Phillips E, Mesganaw T, Patel A, Duttwyler S, Mercado B, Houk K, et al.
Angew Chem Int Ed Engl
. 2015 Sep;
54(41):12044-8.
PMID: 26385263
The asymmetric synthesis of ent-ketorfanol from simple and commercially available precursors is reported. A Rh(I) -catalyzed intramolecular CH alkenylation/torquoselective 6π electrocyclization cascade provides a fused bicyclic 1,2-dihydropyridine as a key...
15.
Cohen D, Eichman C, Phillips E, Zarefsky E, Scheidt K
Angew Chem Int Ed Engl
. 2012 Jun;
51(29):7309-13.
PMID: 22700327
New DKR type: An N-heterocyclic carbene (NHC)-catalyzed dynamic kinetic resolution of racemic α-substituted β-keto esters has been developed. This method relies on the epimerization of an NHC-enol intermediate before subsequent...
16.
Phillips E, Wadamoto M, Scheidt K
Synthesis (Stuttg)
. 2011 Sep;
4:687-690.
PMID: 21085623
The desymmetrization of 1,3-diketones using N-heterocyclic carbenes results in the formation of highly enantioenriched cyclopentenes in good yield. The reaction proceeds through a catalytic intramolecular aldol reaction and subsequent β-lactone...
17.
Phillips E, Chan A, Scheidt K
Aldrichimica Acta
. 2011 Sep;
42(3):55-66.
PMID: 21072130
No abstract available.
18.
Phillips E, Riedrich M, Scheidt K
J Am Chem Soc
. 2010 Sep;
132(38):13179-81.
PMID: 20809579
An efficient intermolecular conjugate addition of alcohols to activated alkenes catalyzed by N-heterocyclic carbenes has been developed. With 5 mol % of the free carbene derived from IMes·HCl, unsaturated ketones...
19.
Phillips E, Roberts J, Scheidt K
Org Lett
. 2010 May;
12(12):2830-3.
PMID: 20469924
A general strategy for the catalytic asymmetric syntheses of the bakkenolides is reported. The key bond-forming step involves an N-heterocyclic carbene catalyzed desymmetrization of a 1,3-diketone to form three new...
20.
Maki B, Chan A, Phillips E, Scheidt K
Tetrahedron
. 2010 Feb;
65(16):3102-3109.
PMID: 20161230
N-Heterocyclic carbenes catalyze the oxidation of allylic and benzylic alcohols as well as saturated aldehydes to esters with manganese(IV) oxide in excellent yields. A variety of esters can be synthesized,...