Eric K Lei
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Explore the profile of Eric K Lei including associated specialties, affiliations and a list of published articles.
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10
Citations
169
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Recent Articles
1.
Lei E, Azmat A, Henry K, Hussack G
Appl Microbiol Biotechnol
. 2024 Feb;
108(1):232.
PMID: 38396192
Bacterial outer membrane vesicles (OMVs) are nanosized spheroidal particles shed by gram-negative bacteria that contain biomolecules derived from the periplasmic space, the bacterial outer membrane, and possibly other compartments. OMVs...
2.
Aguilar E, Sagar S, Murray B, Rajesh C, Lei E, Michaud S, et al.
Mol Cancer Ther
. 2024 Feb;
23(6):836-853.
PMID: 38394685
Mucin-16 (MUC16) is a target for antibody-mediated immunotherapy in pancreatic ductal adenocarcinoma (PDAC) among other malignancies. The MUC16-specific monoclonal antibody AR9.6 has shown promise for PDAC immunotherapy and imaging. Here,...
3.
Lowden M, Lei E, Hussack G, Henry K
Methods Mol Biol
. 2023 Sep;
2702:489-540.
PMID: 37679637
Next-generation DNA sequencing (NGS) technologies have made it possible to interrogate antibody repertoires to unprecedented depths, typically via sequencing of cDNAs encoding immunoglobulin variable domains. In the absence of heavy-light...
4.
Lei E, Ryan S, van Faassen H, Foss M, Robotham A, Baltat I, et al.
Appl Microbiol Biotechnol
. 2023 Jun;
107(14):4567-4580.
PMID: 37284893
Acinetobacter baumannii is a Gram-negative bacterial pathogen that exhibits high intrinsic resistance to antimicrobials, with treatment often requiring the use of last-resort antibiotics. Antibiotic-resistant strains have become increasingly prevalent, underscoring...
5.
Jimenez-Sanchez A, Lei E, Kelley S
Angew Chem Int Ed Engl
. 2018 May;
57(29):8891-8895.
PMID: 29808513
The measurement of physicochemical parameters in living cells can provide information on individual cellular organelles, helping us to understand subcellular function in health and disease. While organelle-specific chemical probes have...
6.
Lei E, Kelley S
J Am Chem Soc
. 2017 Jul;
139(28):9455-9458.
PMID: 28664723
Mitochondria-penetrating peptides (MPPs) are specific targeting vectors for the localization of small molecules to the mitochondrial matrix. Mitochondrial targeting of small molecules has enabled the development of a number of...
7.
Jean S, Ahmed M, Lei E, Wisnovsky S, Kelley S
Acc Chem Res
. 2016 Aug;
49(9):1893-902.
PMID: 27529125
Mitochondria are organelles with critical roles in key processes within eukaryotic cells, and their dysfunction is linked with numerous diseases including neurodegenerative disorders and cancer. Pharmacological manipulation of mitochondrial function...
8.
Wisnovsky S, Lei E, Jean S, Kelley S
Cell Chem Biol
. 2016 Aug;
23(8):917-27.
PMID: 27478157
Mitochondria are energy-producing organelles with essential functions in cell biology, and mitochondrial dysfunction is linked to a wide range of human diseases. Efforts to better understand mitochondrial biology have been...
9.
Jean S, Tulumello D, Wisnovsky S, Lei E, Pereira M, Kelley S
ACS Chem Biol
. 2014 Jan;
9(2):323-33.
PMID: 24410267
The mitochondria within human cells play a major role in a variety of critical processes involved in cell survival and death. An understanding of mitochondrial involvement in various human diseases...
10.
Lei E, Pereira M, Kelley S
Angew Chem Int Ed Engl
. 2013 Jul;
52(37):9660-3.
PMID: 23893882
No abstract available.