Eric J Martin
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Explore the profile of Eric J Martin including associated specialties, affiliations and a list of published articles.
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23
Citations
203
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Recent Articles
1.
Martin E, Santacruz C, Mitevska A, Jones I, Krishnan G, Gao F, et al.
bioRxiv
. 2024 Apr;
PMID: 38585915
A hexanucleotide repeat expansion (HRE) in is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, patients with the HRE exhibit a wide disparity...
2.
Thomas J, Shelton 4th C, Murphy J, Brittain S, Bray M, Aspesi P, et al.
ACS Chem Biol
. 2024 Apr;
19(4):938-952.
PMID: 38565185
Phenotypic assays have become an established approach to drug discovery. Greater disease relevance is often achieved through cellular models with increased complexity and more detailed readouts, such as gene expression...
3.
Godinez W, Trifonov V, Fang B, Kuzu G, Pei L, Guiguemde W, et al.
J Chem Inf Model
. 2024 Jan;
64(7):2695-2704.
PMID: 38293736
Predicting compound activity in assays is a long-standing challenge in drug discovery. Computational models based on compound-induced gene expression signatures from a single profiling assay have shown promise toward predicting...
4.
Mitevska A, Santacruz C, Martin E, Jones I, Ghiacy A, Dixon S, et al.
Neurotrauma Rep
. 2023 Nov;
4(1):682-692.
PMID: 37908320
Human induced pluripotent stem cell (hiPSC)-derived cells can reproduce human-specific pathophysiology, patient-specific vulnerability, and gene-environment interactions in neurological disease. Human models of neurotrauma therefore have great potential to advance the...
5.
Barry J, Litvin S, DeVogelaere A, Caress D, Lovera C, Kahn A, et al.
Sci Adv
. 2023 Aug;
9(34):eadg3247.
PMID: 37611094
Does warmth from hydrothermal springs play a vital role in the biology and ecology of abyssal animals? Deep off central California, thousands of octopus () migrate through cold dark waters...
6.
Born J, Shoshan Y, Huynh T, Cornell W, Martin E, Manica M
J Chem Inf Model
. 2022 Sep;
62(18):4295-4299.
PMID: 36098536
Recent work showed that active site rather than full-protein-sequence information improves predictive performance in kinase-ligand binding affinity prediction. To refine the notion of an "active site", we here propose and...
7.
Mumford K, Martin E, Kueper B
J Contam Hydrol
. 2021 Oct;
243:103892.
PMID: 34634516
The removal of dissolved volatile organic compounds (VOCs) from low-permeability lenses is important to limit back diffusion at sites impacted by dense non-aqueous phase liquids (DNAPLs). In situ thermal treatment...
8.
Martin E, Zhu X
J Chem Inf Model
. 2021 Apr;
61(4):1603-1616.
PMID: 33844519
Massively multitask bioactivity models that transfer learning between thousands of assays have been shown to work dramatically better than separate models trained on each individual assay. In particular, the applicability...
9.
Bosc N, Felix E, Arcila R, Mendez D, Saunders M, Green D, et al.
J Cheminform
. 2021 Feb;
13(1):13.
PMID: 33618772
Malaria is a disease affecting hundreds of millions of people across the world, mainly in developing countries and especially in sub-Saharan Africa. It is the cause of hundreds of thousands...
10.
Charlton J, Jung E, Mattei A, Bailly N, Liao J, Martin E, et al.
Nat Genet
. 2020 Jun;
52(8):819-827.
PMID: 32514123
Mammalian cells stably maintain high levels of DNA methylation despite expressing both positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent and combined effects of these regulators on...