Eric Hay
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Explore the profile of Eric Hay including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Latourte A, Jaulerry S, Combier A, Cherifi C, Jouan Y, Grange T, et al.
Ann Rheum Dis
. 2024 Aug;
83(12):1781-1790.
PMID: 39134394
Objectives: Inflammatory mediators such as interleukin 6 (IL-6) are known to activate catabolic responses in chondrocytes during osteoarthritis (OA). This study aimed to investigate the role of a downstream target...
2.
Jouan Y, Bouchemla Z, Bardeche-Trystram B, Sana J, Andrique C, Ea H, et al.
Sci Adv
. 2022 Aug;
8(34):eabn3106.
PMID: 36026443
Articular cartilage has low regenerative capacity despite permanent stress. Irreversible cartilage lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a, an RNA binding protein, is detected in...
3.
Zarka M, Hay E, Cohen-Solal M
Front Cell Dev Biol
. 2022 Jan;
9:788773.
PMID: 35059398
YAP and TAZ were initially described as the main regulators of organ growth during development and more recently implicated in bone biology. YAP and TAZ are regulated by mechanical and...
4.
Zarka M, Etienne F, Bourmaud M, Szondi D, Schwartz J, Kampmann K, et al.
Lab Invest
. 2021 Sep;
101(12):1597-1604.
PMID: 34521992
Osteocytes are mechanosensitive cells that control bone remodeling in response to mechanical loading. To date, specific signaling pathways modulated by mechanical loading in osteocytes are not well understood. Yes associated...
5.
Bourmaud M, Zarka M, Cozannet R, Fanca-Berthon P, Hay E, Cohen-Solal M
Biomolecules
. 2021 Feb;
11(2).
PMID: 33572124
Osteoarthritis is characterized by cartilage loss resulting from the activation of chondrocytes associated with a synovial inflammation. Activated chondrocytes promote an increased secretion of matrix proteases and proinflammatory cytokines leading...
6.
Shamdani S, Chantepie S, Flageollet C, Henni-Chebra N, Jouan Y, Eymard F, et al.
Arthritis Res Ther
. 2020 Dec;
22(1):283.
PMID: 33287871
Background: Heparan sulfate (HS) proteoglycans (PG) may be found at the chondrocyte surface and in the pericellular cartilage matrix, and are involved in cell-cell and cell-matrix interactions. An important function...
7.
Andrique C, Morardet L, Linares L, Cisse M, Merle C, Chibon F, et al.
JCI Insight
. 2018 Sep;
3(17).
PMID: 30185659
Sarcomas are still unsolved therapeutic challenges. Cancer stem cells are believed to contribute to sarcoma development, but lack of specific markers prevents their characterization and targeting. Here, we show that...
8.
Mansouri R, Jouan Y, Hay E, Blin-Wakkach C, Frain M, Ostertag A, et al.
Cell Death Dis
. 2018 Jul;
9(8):788.
PMID: 30013102
The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information.
9.
Lin H, Hay E, Latourte A, Funck-Brentano T, Bouaziz W, Ea H, et al.
Sci Rep
. 2018 Jul;
8(1):10488.
PMID: 29992982
Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function....
10.
Mansouri R, Jouan Y, Hay E, Blin-Wakkach C, Frain M, Ostertag A, et al.
Cell Death Dis
. 2017 Jun;
8(6):e2902.
PMID: 28661485
Stimulating bone formation is an important challenge for bone anabolism in osteoporotic patients or to repair bone defects. The osteogenic properties of matrix glycosaminoglycans (GAGs) have been explored; however, the...