Eric D Roche
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Explore the profile of Eric D Roche including associated specialties, affiliations and a list of published articles.
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12
Citations
207
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Recent Articles
1.
Slade H, Reece B, McCoy N, Roche E, Jovanovic A, Shi L, et al.
Adv Wound Care (New Rochelle)
. 2025 Jan;
PMID: 39853227
SN514 is a thermolysin-like enzyme under development as a debrider. Preclinical and non-clinical studies supported a first in human healthy volunteer study to predict the need for protection of periwound...
2.
Stone R, Jockheck-Clark A, Natesan S, Rizzo J, Wienandt N, Scott L, et al.
J Burn Care Res
. 2020 Jul;
41(5):1015-1028.
PMID: 32615590
Necrotic tissue generated by a thermal injury is typically removed via surgical debridement. However, this procedure is commonly associated with blood loss and the removal of viable healthy tissue. For...
3.
Roche E, Woodmansey E, Yang Q, Gibson D, Zhang H, Schultz G
Int Wound J
. 2019 Mar;
16(3):674-683.
PMID: 30868761
Biofilms are prevalent in non-healing chronic wounds and implicated in delayed healing. Tolerance to antimicrobial treatments and the host's immune system leave clinicians with limited interventions against biofilm populations. It...
4.
Fitzgerald D, Renick P, Forrest E, Tetens S, Earnest D, McMillan J, et al.
Wound Repair Regen
. 2016 Nov;
25(1):13-24.
PMID: 27859922
Examination of clinical samples indicates bacterial biofilms are present in the majority of chronic wounds, and substantial evidence suggests biofilms contribute significantly to delayed healing. Bacteria in biofilms are highly...
5.
Roche E, Renick P, Tetens S, Ramsay S, Daniels E, Carson D
Wound Repair Regen
. 2012 Jun;
20(4):537-43.
PMID: 22672311
Data supporting the concept that microbial biofilms are a major cause of non-healing ulcers remain limited. A porcine model was established where delayed healing resulted from methicillin-resistant Staphylococcus aureus (MRSA)...
6.
Roche E, Renick P, Tetens S, Carson D
Antimicrob Agents Chemother
. 2012 May;
56(8):4508-10.
PMID: 22644024
A wound biofilm model was created by adapting a superficial infection model. Partial-thickness murine wounds were inoculated with methicillin-resistant Staphylococcus aureus (MRSA). Dense biofilm communities developed at the wound surface...
7.
Cargill D, Roche E, Van Der Kar C, Slade H, Aust D, Carson D, et al.
Am J Infect Control
. 2011 Apr;
39(3):226-34.
PMID: 21458685
Background: Health care handwashes/sanitizers help prevent the spread of infection. Many are alcohol-based, providing immediate microbial kill. Few contain persistence factors for residual antimicrobial effects. We conducted multiple studies on...
8.
Robertson G, Bonventre E, Doyle T, Du Q, Duncan L, Morris T, et al.
Antimicrob Agents Chemother
. 2008 Apr;
52(7):2313-23.
PMID: 18443108
Rifamycins have proven efficacy in the treatment of persistent bacterial infections. However, the frequency with which bacteria develop resistance to rifamycin agents restricts their clinical use to antibiotic combination regimens....
9.
Robertson G, Bonventre E, Doyle T, Du Q, Duncan L, Morris T, et al.
Antimicrob Agents Chemother
. 2008 Apr;
52(7):2324-34.
PMID: 18443106
We present data from antimicrobial assays performed in vitro that pertain to the potential clinical utility of a novel rifamycin-quinolone hybrid antibiotic, CBR-2092, for the treatment of infections mediated by...
10.
Fischbach M, Lai J, Roche E, Walsh C, Liu D
Proc Natl Acad Sci U S A
. 2007 Jul;
104(29):11951-6.
PMID: 17620609
Nonribosomal peptides (NRPs) are produced by NRP synthetase (NRPS) enzymes that function as molecular assembly lines. The modular architecture of NRPSs suggests that a domain responsible for activating a building...