Erawan Borkham-Kamphorst
Overview
Explore the profile of Erawan Borkham-Kamphorst including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1384
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Recent Articles
1.
Borkham-Kamphorst E, Meurer S, Weiskirchen R
J Cell Commun Signal
. 2023 May;
17(2):307-320.
PMID: 37166689
The cellular (centralized) communication network (CCN) factor protein family contains six small secreted cysteine-rich proteins sharing high structural similarity. These matricellular proteins have vital biological functions in cell adhesion, migration,...
2.
Borkham-Kamphorst E, Haas U, Pinoe-Schmidt M, Abdallah A, Weiskirchen R
Lab Invest
. 2021 Sep;
101(12):1528-1539.
PMID: 34518636
Lipocalin 2 (LCN2), an acute-phase protein produced during acute liver injury, plays an important role in the innate immune response against bacterial infection via iron scavenging. LCN2 further influences neutrophil...
3.
Borkham-Kamphorst E, Haas U, Van de Leur E, Trevanich A, Weiskirchen R
Int J Mol Sci
. 2020 Jul;
21(15).
PMID: 32718038
The lack of Lipocalin (LCN2) provokes overwhelming endoplasmic reticulum (ER) stress responses in vitro and in acute toxic liver injury models, resulting in hepatocyte apoptosis. LCN2 is an acute phase...
4.
Buniatian G, Weiskirchen R, Weiss T, Schwinghammer U, Fritz M, Seferyan T, et al.
Cells
. 2020 Feb;
9(2).
PMID: 32089540
The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in...
5.
Schwinghammer U, Melkonyan M, Hunanyan L, Tremmel R, Weiskirchen R, Borkham-Kamphorst E, et al.
Cells
. 2020 Feb;
9(2).
PMID: 32085378
The noradrenergic system is proposed to play a prominent role in the pathogenesis of liver fibrosis. While α1- and β-adrenergic receptors (ARs) are suggested to be involved in a multitude...
6.
Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, et al.
EMBO Mol Med
. 2020 Jan;
12(3):e11021.
PMID: 31943786
Kidney fibrosis is characterized by expansion and activation of platelet-derived growth factor receptor-β (PDGFR-β)-positive mesenchymal cells. To study the consequences of PDGFR-β activation, we developed a model of primary renal...
7.
Winkler I, Bitter C, Winkler S, Weichenhan D, Thavamani A, Hengstler J, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(1):454-463.
PMID: 31871210
Liver fibrosis interferes with normal liver function and facilitates hepatocellular carcinoma (HCC) development, representing a major threat to human health. Here, we present a comprehensive perspective of microRNA (miRNA) function...
8.
Borkham-Kamphorst E, Van de Leur E, Haas U, Weiskirchen R
Cell Signal
. 2019 Jan;
55:90-99.
PMID: 30615971
Unfolded protein response (UPR) is an adaptive mechanism allowing the endoplasmic reticulum (ER) to react to an accumulation of unfolded proteins in its lumen, also known as ER stress. The...
9.
Borkham-Kamphorst E, Steffen B, Van de Leur E, Haas U, Weiskirchen R
Cell Signal
. 2018 Jul;
51:72-85.
PMID: 30044965
Portal fibroblasts are mesenchyme-derived fibroblasts surrounding the bile ducts, and activated into portal myofibroblasts (pMF) during cholestatic liver injury. pMF express α-smooth muscle actin (α-SMA) and produce the fibrogenic extracellular...
10.
Borkham-Kamphorst E, Van de Leur E, Meurer S, Buhl E, Weiskirchen R
Front Pharmacol
. 2018 May;
9:426.
PMID: 29755357
Lipocalin 2 (LCN2) is a highly conserved secreted adipokine acting as a serum transport protein for small hydrophobic molecules such as fatty acids and steroids. In addition, LCN2 limits bacterial...