Eoin C Whelan
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Explore the profile of Eoin C Whelan including associated specialties, affiliations and a list of published articles.
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9
Citations
74
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Recent Articles
1.
Whelan E, Swain J, Sussman J, Smith D, Yang F, Rotolo A, et al.
Stem Cell Reports
. 2025 Mar;
:102449.
PMID: 40086448
Spermatogenesis is driven by dramatic changes in chromatin regulation, gene transcription, and protein expression. To assess the mechanistic bases for these developmental changes, we utilized multiomic single-cell/nucleus RNA sequencing (sc/snRNA-seq)...
2.
Cheng K, Seita Y, Whelan E, Yokomizo R, Hwang Y, Rotolo A, et al.
Cell Rep
. 2024 Jun;
43(6):114323.
PMID: 38861385
Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome...
3.
Walzer K, Tandel J, Byerly J, Daniels A, Gullicksrud J, Whelan E, et al.
Nature
. 2024 May;
630(8015):174-180.
PMID: 38811723
The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children, and a cause and consequence of chronic malnutrition. There are no vaccines and only limited treatment options....
4.
Rotolo A, Whelan E, Atherton M, Kulikovskaya I, Jarocha D, Fraietta J, et al.
Cell Rep Med
. 2023 Oct;
4(10):101241.
PMID: 37852175
Allogeneic invariant natural killer T cells (allo-iNKTs) induce clinical remission in patients with otherwise incurable cancers and COVID-19-related acute respiratory failure. However, their functionality is inconsistent among individuals, and they...
5.
Whelan E, Yang F, Avarbock M, Sullivan M, Beiting D, Brinster R
PLoS Biol
. 2022 May;
20(5):e3001618.
PMID: 35536782
Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys...
6.
Sinha N, Whelan E, Tobias J, Avarbock M, Stefanovski D, Brinster R
Biol Reprod
. 2021 May;
105(2):503-518.
PMID: 33959758
Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it operates remains largely unknown. We developed a germ cell culture assay system to study genes involved in spermatogonial...
7.
Yang F, Whelan E, Guan X, Deng B, Wang S, Sun J, et al.
Cell Prolif
. 2020 Oct;
54(1):e12933.
PMID: 33107118
Objectives: Fibroblast growth factor 9 (FGF9) is expressed by somatic cells in the seminiferous tubules, yet little information exists about its role in regulating spermatogonial stem cells (SSCs). Materials And...
8.
Sinha N, Whelan E, Brinster R
Methods Mol Biol
. 2019 Jun;
2005:205-220.
PMID: 31175655
Spermatogonial stem cell (SSC) culture and transplantation pave the way for clinical restoration of fertility in male prepubertal cancer survivors. In this chapter we detail the steps for isolating and...
9.
Whelan E, Nwala A, Osgood C, Olariu S
Bioinformatics
. 2016 Aug;
32(24):3790-3797.
PMID: 27531106
Motivation: As the mean age of parenthood grows, the effect of parental age on genetic disease and child health becomes ever more important. A number of autosomal dominant disorders show...
10.
Mahadevan K, Patthipati V, Han S, Swanson R, Whelan E, Osgood C, et al.
Nanotechnology
. 2016 Jul;
27(33):335101.
PMID: 27378394
Nanomaterial based imaging approaches hold substantial promise in addressing current diagnostic and therapeutic challenges. One of the key requirements for the successful clinical translation of nanomaterials is their complete clearance...