Antonia Rotolo
Overview
Explore the profile of Antonia Rotolo including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
322
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Recent Articles
1.
Whelan E, Swain J, Sussman J, Smith D, Yang F, Rotolo A, et al.
Stem Cell Reports
. 2025 Mar;
:102449.
PMID: 40086448
Spermatogenesis is driven by dramatic changes in chromatin regulation, gene transcription, and protein expression. To assess the mechanistic bases for these developmental changes, we utilized multiomic single-cell/nucleus RNA sequencing (sc/snRNA-seq)...
2.
Yoshimoto S, Kudo A, Rotolo A, Foos K, Olenick L, Takagi S, et al.
iScience
. 2024 Sep;
27(9):110863.
PMID: 39314237
Chimeric antigen receptor (CAR) T cell therapy has achieved unprecedented clinical outcomes in patients with relapsed/refractory B cell leukemias; however, response rates in patients with large B cell lymphoma (LBCL)...
3.
Patel R, Ghilardi G, Zhang Y, Chiang Y, Xie W, Guruprasad P, et al.
Sci Immunol
. 2024 Jul;
9(97):eadn6509.
PMID: 39028827
Most patients treated with US Food and Drug Administration (FDA)-approved chimeric antigen receptor (CAR) T cells eventually experience disease progression. Furthermore, CAR T cells have not been curative against solid...
4.
Cheng K, Seita Y, Whelan E, Yokomizo R, Hwang Y, Rotolo A, et al.
Cell Rep
. 2024 Jun;
43(6):114323.
PMID: 38861385
Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome...
5.
Rotolo A, Atherton M
Clin Cancer Res
. 2024 Apr;
30(11):2359-2369.
PMID: 38573683
Chimeric antigen receptor (CAR) T-adoptive cell therapy has transformed the treatment of human hematologic malignancies. However, its application for the treatment of solid tumors remains challenging. An exciting avenue for...
6.
Rotolo A, Whelan E, Atherton M, Kulikovskaya I, Jarocha D, Fraietta J, et al.
Cell Rep Med
. 2023 Oct;
4(10):101241.
PMID: 37852175
Allogeneic invariant natural killer T cells (allo-iNKTs) induce clinical remission in patients with otherwise incurable cancers and COVID-19-related acute respiratory failure. However, their functionality is inconsistent among individuals, and they...
7.
Watanabe K, Gomez A, Kuramitsu S, Siurala M, Da T, Agarwal S, et al.
Blood Adv
. 2023 Apr;
7(14):3416-3430.
PMID: 37058474
A challenge when targeting T-cell lymphoma with chimeric antigen receptor (CAR) T-cell therapy is that target antigens are often shared between T cells and tumor cells, resulting in fratricide between...
8.
Atherton M, Rotolo A, Haran K, Mason N
Front Vet Sci
. 2022 Jul;
9:824982.
PMID: 35898541
Background: Chimeric antigen receptor-T (CAR-T) cells have transformed the treatment of human B cell malignancies. With the advent of CAR-T therapy, specific and in some cases severe toxicities have been...
9.
Mason N, Chester N, Xiong A, Rotolo A, Wu Y, Yoshimoto S, et al.
MAbs
. 2021 Dec;
13(1):2004638.
PMID: 34856888
The immune checkpoint inhibitor (ICI) ipilimumab has revolutionized the treatment of patients with different cancer histologies, including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset...
10.
Rotolo A, Atherton M, Kasper B, Haran K, Mason N
STAR Protoc
. 2021 Nov;
2(4):100905.
PMID: 34746864
Immunocompetent pet dogs develop spontaneous, human-like cancers, representing a parallel patient population for the investigation of chimeric antigen receptor (CAR) therapies. We have optimized a retrovirus-based protocol to efficiently CAR...