Emmanuelle Briard
Overview
Explore the profile of Emmanuelle Briard including associated specialties, affiliations and a list of published articles.
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26
Citations
436
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Recent Articles
1.
Whitehead D, Fischer C, Briard E, Farady C, Graveleau N, Karrer J, et al.
ChemMedChem
. 2024 Nov;
20(4):e202400816.
PMID: 39540320
We describe the identification of a candidate positron emission tomography (PET) imaging agent for the NLRP3 protein. NLRP3 plays a critical role in the immune system and has proven a...
2.
Briard E, Serrand Y, Dahirel P, Janvier R, Noirot V, Etienne P, et al.
Front Nutr
. 2023 Mar;
10:1123162.
PMID: 36925960
Introduction: In the present study, we examined the effects of a supplementation with a sensory functional ingredient (FI, D16729, Phodé, France) containing vanillin, furaneol, diacetyl and a mixture of aromatic...
3.
Auberson Y, Lievre A, Desrayaud S, Briard E
J Labelled Comp Radiopharm
. 2022 Sep;
65(13):343-350.
PMID: 36148533
The discovery of novel imaging agents for positron emission tomography (PET) relies on medicinal chemistry best practices, including a good understanding of molecular and pharmacological properties required for the acquisition...
4.
Bestea L, Briard E, Carcaud J, Sandoz J, Velarde R, Giurfa M, et al.
Biol Lett
. 2022 Feb;
18(2):20210520.
PMID: 35104428
Motivation can critically influence learning and memory. Multiple neural mechanisms regulate motivational states, among which signalling via specific neuropeptides, such as NPY in vertebrates and NPF and its short variant...
5.
Bigaud M, Rudolph B, Briard E, Beerli C, Hofmann A, Hermes E, et al.
Mult Scler J Exp Transl Clin
. 2021 Nov;
7(4):20552173211049168.
PMID: 34777855
Background: Siponimod (BAF312), a selective S1P/S1P agonist, reduces disability progression in secondary progressive MS. Recent observations suggest it could act via S1P/S1P-dependent anti-inflammatory and pro-myelination effects on CNS-resident cells. Objective:...
6.
Vermeulen K, Cools R, Briard E, Auberson Y, Schoepfer J, Koole M, et al.
ACS Chem Neurosci
. 2021 Oct;
12(20):3915-3927.
PMID: 34597516
Aberrant Hsp90 has been implied in cancer and neurodegenerative disorders. The development of a suitable Hsp90 Positron emission tomography (PET) probe can provide quantification of the expression levels of Hsp90...
7.
Litchfield M, Wuest M, Glubrecht D, Briard E, Auberson Y, McMullen T, et al.
Mol Pharm
. 2021 Jul;
18(9):3352-3364.
PMID: 34319110
Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). The ATX/LPA signaling axis is typically activated in wound healing and tissue repair processes. The ATX/LPA axis is...
8.
He Y, Whitehead D, Briard E, Numao S, Mu L, Schibli R, et al.
ChemMedChem
. 2020 Jun;
15(24):2448-2461.
PMID: 32544308
We describe here our efforts to develop a PET tracer for imaging GluN2A-containing NMDA receptors, based on a 5H-thiazolo[3,2-α]pyrimidin-5-one scaffold. The metabolic stability and overall properties could be optimized satisfactorily,...
9.
Gobbi L, Mercier J, Bang-Andersen B, Nicolas J, Reilly J, Wagner B, et al.
ChemMedChem
. 2019 Dec;
15(7):585-592.
PMID: 31797561
Nonspecific binding (NSB) is a key parameter in optimizing PET imaging tracers. We compared the ability to predict NSB of three available methods: LIMBA, rat f , and CHI(IAM). Even...
10.
Briard E, Joshi A, Shanmukhappa S, Ilovich O, Auberson Y
ChemMedChem
. 2019 Jul;
14(16):1493-1502.
PMID: 31273951
Autotaxin (ATX) is a secreted enzyme with tissue levels associated with tissue injury, which increase during wound healing and chronic fibrotic diseases. We selected [ F](R,E)-3-(4-chloro-2-((5-methyl-2H-tetrazol-2-yl)methyl)phenyl)-1-(4-((5-(2-fluoroethoxy)pyridin-2-yl)methyl)-2-methylpiperazin-1-yl)prop-2-en-1-one ([ F]PRIMATX, [ F]2),...