Emmanuelle Briard
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Explore the profile of Emmanuelle Briard including associated specialties, affiliations and a list of published articles.
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26
Citations
436
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Recent Articles
11.
Auberson Y, Briard E, Rudolph B, Kaupmann K, Smith P, Oberhauser B
ChemMedChem
. 2018 Jun;
13(15):1566-1579.
PMID: 29856125
Imaging T cells using positron emission tomography (PET) would be highly useful for diagnosis and monitoring in immunology and oncology patients. There are, however, no obvious targets that can be...
12.
Auberson Y, Brocklehurst C, Furegati M, Fessard T, Koch G, Decker A, et al.
ChemMedChem
. 2017 Mar;
12(8):590-598.
PMID: 28319646
Bicycloalkyl groups have been previously described as phenyl group bioisosteres. This article describes the synthesis of new building blocks allowing their introduction into complex molecules, and explores their use as...
13.
Auberson Y, Briard E, Sykes D, Reilly J, Healy M
ChemMedChem
. 2016 May;
11(13):1415-27.
PMID: 27193393
Ligand efficiency indices are widely used to guide chemical optimization in drug discovery, due to their predictive value in the early steps of optimization. At later stages, however, as more...
14.
Briard E, Rudolph B, Desrayaud S, Krauser J, Auberson Y
ChemMedChem
. 2015 May;
10(6):1008-18.
PMID: 25924727
BAF312 (siponimod) is a sphingosine-1-phosphate (S1P) receptor modulator in clinical development for the treatment of multiple sclerosis, with faster organ/tissue distribution and elimination kinetics than its precursor FTY720 (fingolimod). Our...
15.
Callander G, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, et al.
Front Neurosci
. 2013 Dec;
7:230.
PMID: 24376396
Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics...
16.
Lee Y, Simeon F, Briard E, Pike V
ACS Chem Neurosci
. 2012 Aug;
3(4):325-35.
PMID: 22860199
Eighteen kilodalton translocator protein (TSPO) is an important target for drug discovery and for clinical molecular imaging of brain and peripheral inflammatory processes. PK 11195 [1a; 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3-isoquinoline carboxamide] is the...
17.
Briard E, Orain D, Beerli C, Billich A, Streiff M, Bigaud M, et al.
ChemMedChem
. 2011 Feb;
6(4):667-77.
PMID: 21280229
FTY720 (fingolimod, Gilenya®) is a sphingosine 1-phosphate (S1P) receptor modulator that shows significant therapeutic efficacy after oral administration to patients of multiple sclerosis. Because FTY720 does not contain any atom...
18.
Jiang Z, Reilly J, Everatt B, Briard E
J Pharm Biomed Anal
. 2010 Dec;
54(4):722-9.
PMID: 21126842
High non-specific binding (NSB) is one of the most common reasons for candidate failure in potential positron emission tomography (PET) radiotracer development. It is of interest to develop high throughput...
19.
Briard E, Zoghbi S, Simeon F, Imaizumi M, Gourley J, Shetty H, et al.
J Med Chem
. 2009 Jan;
52(3):688-99.
PMID: 19119848
Elevated levels of peripheral benzodiazepine receptors (PBR) are associated with activated microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for investigating brain inflammatory conditions. Sensitive,...
20.
Briard E, Zoghbi S, Imaizumi M, Gourley J, Shetty H, Hong J, et al.
J Med Chem
. 2007 Dec;
51(1):17-30.
PMID: 18067245
We sought to develop (11)C-labeled ligands for sensitive imaging of brain peripheral benzodiazepine receptors (PBR) in vivo. Two aryloxyanilides with high affinity for PBR were identified and synthesized, namely, N-acetyl-...