Emmanuel Giudice
Overview
Explore the profile of Emmanuel Giudice including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
695
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0
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Recent Articles
1.
Morin C, Baudin-Baillieu A, Nguyen Van Long F, Isaac C, Bidou L, Arbes H, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2408114121.
PMID: 39636864
Epithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological...
2.
DUrso G, Chat S, Gillet R, Giudice E
Nucleic Acids Res
. 2023 Feb;
51(7):3410-3419.
PMID: 36840711
The multidomain ribosomal protein bS1 is the biggest and the most flexible and dynamic protein in the 30S small subunit. Despite being essential for mRNA recruitment and its primary role...
3.
Giudice E, Georgeault S, Lavigne R, Pineau C, Trautwetter A, Ermel G, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834906
Ribosome biogenesis is a complex and multistep process that depends on various assembly factors. To understand this process and identify the ribosome assembly intermediates, most studies have set out to...
4.
Mansour M, Giudice E, Xu X, Akarsu H, Bordes P, Guillet V, et al.
Nat Commun
. 2022 May;
13(1):2641.
PMID: 35552387
Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth. Here, we focus on the deleterious toxin of the atypical tripartite toxin-antitoxin-chaperone (TAC) system of Mycobacterium tuberculosis, whose inhibition...
5.
Campos-Silva R, DUrso G, Delalande O, Giudice E, Macedo A, Gillet R
Microorganisms
. 2022 Jan;
10(1).
PMID: 35056452
Because of the ever-increasing multidrug resistance in microorganisms, it is crucial that we find and develop new antibiotics, especially molecules with different targets and mechanisms of action than those of...
6.
DUrso G, Guyomar C, Chat S, Giudice E, Gillet R
FEBS J
. 2022 Jan;
290(6):1461-1472.
PMID: 35015931
The arrest of protein synthesis caused when ribosomes stall on an mRNA lacking a stop codon is a deadly risk for all cells. In bacteria, this situation is remedied by...
7.
Gomes Von Borowski R, Chat S, Schneider R, Nonin-Lecomte S, Bouaziz S, Giudice E, et al.
Microbiol Spectr
. 2021 Oct;
9(2):e0047121.
PMID: 34704807
Staphylococci are pathogenic biofilm-forming bacteria and a source of multidrug resistance and/or tolerance causing a broad spectrum of infections. These bacteria are enclosed in a matrix that allows them to...
8.
Guyomar C, DUrso G, Chat S, Giudice E, Gillet R
Nat Commun
. 2021 Aug;
12(1):4909.
PMID: 34389707
In bacteria, trans-translation is the main rescue system, freeing ribosomes stalled on defective messenger RNAs. This mechanism is driven by small protein B (SmpB) and transfer-messenger RNA (tmRNA), a hybrid...
9.
Gomes Von Borowski R, Barros M, da Silva D, Lopes N, Zimmer K, Staats C, et al.
Int J Pharm
. 2019 Dec;
574:118872.
PMID: 31812797
Medical devices (indwelling) have greatly improved healthcare. Nevertheless, infections related to the use of these apparatuses continue to be a major clinical concern. Biofilms form on surfaces after bacterial adhesion,...
10.
Dystrophin's central domain forms a complex filament that becomes disorganized by in-frame deletions
Delalande O, Molza A, Dos Santos Morais R, Cheron A, Pollet E, Raguenes-Nicol C, et al.
J Biol Chem
. 2018 Mar;
293(18):6637-6646.
PMID: 29535188
Dystrophin, encoded by the gene, is critical for maintaining plasma membrane integrity during muscle contraction events. Mutations in the gene disrupting the reading frame prevent dystrophin production and result in...