Emma S Chambers
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Explore the profile of Emma S Chambers including associated specialties, affiliations and a list of published articles.
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32
Citations
1457
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Recent Articles
1.
Peckham H, Radziszewska A, Sikora J, de Gruijter N, Restuadi R, Kartawinata M, et al.
J Exp Med
. 2025 Mar;
222(4).
PMID: 40049222
Sex differences in immunity are well-documented, though mechanisms underpinning these differences remain ill-defined. Here, in a human-only ex vivo study, we demonstrate that postpubertal cisgender females have higher levels of...
2.
Hindle S, Bachas Brook H, Chrysanthou A, Chambers E, Caley M, Connelly J
Adv Sci (Weinh)
. 2025 Jan;
12(10):e2415717.
PMID: 39836544
To enable in vitro investigation of human skin immunology, this study develops a microfluidic human skin equivalent (HSE) that supports the delivery of circulating immune cells via a vascular microchannel...
3.
Kalailingam P, Ngan S, Iyappan R, Nehchiri A, Mohd-Kahliab K, Lee B, et al.
Aging Cell
. 2025 Jan;
:e14425.
PMID: 39757428
Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable,...
4.
Subramanian P, Sayegh S, Laphanuwat P, Devine O, Fantecelle C, Sikora J, et al.
Aging Cell
. 2024 Oct;
24(2):e14373.
PMID: 39420514
The integrated behaviour of multiple senescent cell types within a single human tissue leading to the development of malignancy is unclear. Patients with Familial Melanoma Syndrome (FMS) have heterozygous germline...
5.
Neunie O, Rabbani W, Baker D, Chambers E, Pfeffer P, Kang A
Hum Antibodies
. 2024 Jun;
32(3):121-128.
PMID: 38905039
Objective: Asthma is a major global disease affecting adults and children, which can lead to hospitalization and death due to breathing difficulties. Although targeted monoclonal antibody therapies have revolutionized treatment...
6.
Chambers E, Cai W, Vivaldi G, Jolliffe D, Perdek N, Li W, et al.
NPJ Vaccines
. 2024 May;
9(1):87.
PMID: 38778017
Vaccine development targeting SARS-CoV-2 in 2020 was of critical importance in reducing COVID-19 severity and mortality. In the U.K. during the initial roll-out most individuals either received two doses of...
7.
Sayegh S, Fantecelle C, Laphanuwat P, Subramanian P, Rustin M, Gomes D, et al.
Aging Cell
. 2024 Jan;
23(4):e14093.
PMID: 38287646
Vitamin D replacement in older insufficient adults significantly improves their antigen-specific varicella zoster virus (VZV) cutaneous immunity. However, the mechanisms involved in this enhancement of cutaneous immunity are not known....
8.
Chambers E, Vukmanovic-Stejic M, Shih B, Trahair H, Subramanian P, Devine O, et al.
Nat Aging
. 2023 Apr;
1(1):101-113.
PMID: 37118005
We have previously shown that healthy older adults exhibit reduced cutaneous immune responses during a varicella zoster virus (VZV) antigen challenge that correlated with a nonspecific inflammatory response to the...
9.
Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, et al.
Immunother Adv
. 2022 Oct;
1(1):ltaa008.
PMID: 36284901
Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus...
10.
Jolliffe D, Vivaldi G, Chambers E, Cai W, Li W, Faustini S, et al.
Nutrients
. 2022 Sep;
14(18).
PMID: 36145196
Vitamin D deficiency has been reported to associate with the impaired development of antigen-specific responses following vaccination. We aimed to determine whether vitamin D supplements might boost the immunogenicity and...