Emanuele Criscuolo
Overview
Explore the profile of Emanuele Criscuolo including associated specialties, affiliations and a list of published articles.
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11
Citations
33
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Recent Articles
1.
Nana Teukam Y, Zipoli F, Laino T, Criscuolo E, Grisoni F, Manica M
Brief Bioinform
. 2025 Jan;
26(1.
PMID: 39780486
Enzymes are molecular machines optimized by nature to allow otherwise impossible chemical processes to occur. Their design is a challenging task due to the complexity of the protein space and...
2.
Ozcelik R, de Ruiter S, Criscuolo E, Grisoni F
Nat Commun
. 2024 Jul;
15(1):6176.
PMID: 39039051
Generative deep learning is reshaping drug design. Chemical language models (CLMs) - which generate molecules in the form of molecular strings - bear particular promise for this endeavor. Here, we...
3.
Gambardella G, Notari S, Criscuolo E, Lai O, Nardoni A, Massoud R, et al.
Arch Biochem Biophys
. 2024 May;
757:110038.
PMID: 38750920
Oxidized albumin is considered a short-term biomarker of oxidative stress and its measurement in blood contributes to evaluate the impact of diseases, drugs, dialytic treatments, physical activity, environmental contaminants etc....
4.
van Tilborg D, Brinkmann H, Criscuolo E, Rossen L, Ozcelik R, Grisoni F
Curr Opin Struct Biol
. 2024 Apr;
86:102818.
PMID: 38669740
Deep learning is becoming increasingly relevant in drug discovery, from de novo design to protein structure prediction and synthesis planning. However, it is often challenged by the small data regimes...
5.
Criscuolo E, De Sciscio M, De Cristofaro A, Nicoara C, Maccarrone M, Fezza F
Pharmaceuticals (Basel)
. 2023 Dec;
16(12).
PMID: 38139805
The cannabinoid receptor 1 (CB1R) plays a pivotal role in regulating various physiopathological processes, thus positioning itself as a promising and sought-after therapeutic target. However, the search for specific and...
6.
Cantoni V, Green R, Assante R, DAntonio A, Maio F, Criscuolo E, et al.
Cancer Med
. 2023 Mar;
12(10):11396-11407.
PMID: 36999824
Background: Advances in treatment and optimization of chemotherapy protocols have greatly improved survival in cancer patients. Unfortunately, treatment can cause a reduction in left ventricular (LV) ejection fraction (EF) leading...
7.
Fazio D, Criscuolo E, Maccarrone M
Methods Mol Biol
. 2022 Sep;
2576:299-305.
PMID: 36152197
The α,β-hydrolase fold-containing protein 2 (ABHD2) is a serine hydrolase, responsible for the cleavage of endogenous 2-arachidonoylglycerol (2-AG). ABHD2 is activated by progesterone, thus, it is considered a nonnuclear receptor...
8.
Mannarino T, DAntonio A, Assante R, Zampella E, Gaudieri V, Buongiorno P, et al.
Eur J Nucl Med Mol Imaging
. 2022 Sep;
50(1):160-167.
PMID: 36053295
Background: Despite myocardial perfusion imaging (MPI) by cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) camera is largely used in the diagnosis and risk stratification of patients with suspected or known...
9.
Assante R, DAntonio A, Mannarino T, Gaudieri V, Zampella E, Mainolfi C, et al.
Eur J Nucl Med Mol Imaging
. 2021 Nov;
49(5):1544-1552.
PMID: 34773166
Purpose: We assessed the impact of COVID-19 infection on cardiovascular events in patients with suspected or known coronary artery disease (CAD) referred to stress single-photon emission computed tomography myocardial perfusion...
10.
Exploring the Role of L10 Loop in New Delhi Metallo-β-lactamase (NDM-1): Kinetic and Dynamic Studies
Piccirilli A, Criscuolo E, Brisdelli F, Mercuri P, Cherubini S, De Sciscio M, et al.
Molecules
. 2021 Sep;
26(18).
PMID: 34576958
Four NDM-1 mutants (L218T, L221T, L269H and L221T/Y229W) were generated in order to investigate the role of leucines positioned in L10 loop. A detailed kinetic analysis stated that these amino...