Emanuel Candeias
Overview
Explore the profile of Emanuel Candeias including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
444
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Recent Articles
1.
Munoz-Pinto M, Candeias E, Melo-Marques I, Esteves A, Maranha A, Magalhaes J, et al.
Mol Neurodegener
. 2024 Oct;
19(1):78.
PMID: 39449004
Background: In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its microbiota in the disease. Recent evidence suggests the gut microbiota may trigger body-first...
2.
Candeias E, Pereira-Santos A, Empadinhas N, Cardoso S, Esteves A
J Alzheimers Dis
. 2024 Jun;
100(2):413-429.
PMID: 38875045
Accumulating evidence suggests that gut inflammation is implicated in neuroinflammation in Alzheimer's and Parkinson's diseases. Despite the numerous connections it remains unclear how the gut and the brain communicate and...
3.
Pereira-Santos A, Candeias E, Magalhaes J, Empadinhas N, Esteves A, Cardoso S
Biochim Biophys Acta Mol Basis Dis
. 2024 Apr;
1870(5):167167.
PMID: 38626829
The microbial toxin β-N-methylamino-L-alanine (BMAA), which is derived from cyanobacteria, targets neuronal mitochondria, leading to the activation of neuronal innate immunity and, consequently, neurodegeneration. Although known to modulate brain inflammation,...
4.
Magalhaes J, Candeias E, Melo-Marques I, Abreu A, Pereira-Santos A, Esteves A, et al.
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542396
Parkinson's disease (PD) is a progressive neurodegenerative disorder with an unknown cause. Recent research has highlighted the importance of the gut in neuronal and immune maturation through the exchange of...
5.
Magalhaes J, Candeias E, Melo-Marques I, Silva D, Esteves A, Empadinhas N, et al.
Cell Mol Life Sci
. 2023 May;
80(6):166.
PMID: 37249642
Parkinson's disease (PD) is a multifactorial neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. In the prodromal phase several autonomic symptoms including orthostatic hypotension and constipation...
6.
Esteves A, Silva D, Banha D, Candeias E, Guedes B, Cardoso S
Redox Biol
. 2023 Apr;
63:102714.
PMID: 37120929
Sporadic Parkinson's disease (sPD) is a complex multifactorial disorder which etiology remains elusive. Several mechanisms have been described to contribute to PD development namely mitochondrial dysfunction, activation of inflammatory pathways...
7.
Magalhaes J, Esteves A, Candeias E, Silva D, Empadinhas N, Cardoso S
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36901773
Mitochondria play a key role in regulating host metabolism, immunity and cellular homeostasis. Remarkably, these organelles are proposed to have evolved from an endosymbiotic association between an alphaproteobacterium and a...
8.
Diniz A, Alves M, Candeias E, Duarte A, Moreira P, Silva B, et al.
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012191
Diabetes mellitus type 2 (T2DM) has been associated with alterations in the male reproductive tract, especially in the epididymis. Although it is known that T2DM alters epididymal physiology, disturbing mitochondrial...
9.
Esteves A, Munoz-Pinto M, Nunes-Costa D, Candeias E, Silva D, Magalhaes J, et al.
Gut
. 2021 Nov;
72(1):73-89.
PMID: 34836918
Objective: Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by...
10.
Silva D, Candeias E, Esteves A, Magalhaes J, Ferreira I, Nunes-Costa D, et al.
J Neuroinflammation
. 2020 Nov;
17(1):332.
PMID: 33153477
Background: After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer's disease (sAD) still has no known etiology. Adding to the myriad of different pathways involved, bacterial...