Ema Stokasimov
Overview
Explore the profile of Ema Stokasimov including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
170
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Recent Articles
1.
Papathanasiou S, Mynhier N, Liu S, Brunette G, Stokasimov E, Jacob E, et al.
Nature
. 2023 Jun;
619(7968):184-192.
PMID: 37286600
Transcriptional heterogeneity due to plasticity of the epigenetic state of chromatin contributes to tumour evolution, metastasis and drug resistance. However, the mechanisms that cause this epigenetic variation are incompletely understood....
2.
Tang S, Stokasimov E, Cui Y, Pellman D
Nature
. 2022 Apr;
606(7916):930-936.
PMID: 35477155
Chromothripsis is a catastrophic mutational process that promotes tumorigenesis and causes congenital disease. Chromothripsis originates from aberrations of nuclei called micronuclei or chromosome bridges. These structures are associated with fragile...
3.
Lee I, Stokasimov E, Dempsey N, Varberg J, Jacob E, Jaspersen S, et al.
J Cell Biol
. 2020 Apr;
219(6).
PMID: 32243490
The nuclear envelope (NE) undergoes dynamic remodeling to maintain NE integrity, a process involving the inner nuclear membrane protein LEM2 recruiting CHMP7/Cmp7 and then ESCRT-III. However, prior work has hinted...
4.
Arellano-Santoyo H, Geyer E, Stokasimov E, Chen G, Su X, Hancock W, et al.
Dev Cell
. 2017 Jul;
42(1):37-51.e8.
PMID: 28697331
Kinesin-8 motors regulate the size of microtubule structures, using length-dependent accumulation at the plus end to preferentially disassemble long microtubules. Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate....
5.
Buttery S, Kono K, Stokasimov E, Pellman D
Mol Biol Cell
. 2012 Aug;
23(20):4041-53.
PMID: 22918953
Formin-family proteins promote the assembly of linear actin filaments and are required to generate cellular actin structures, such as actin stress fibers and the cytokinetic actomyosin contractile ring. Many formin...
6.
Wen K, McKane M, Stokasimov E, Rubenstein P
J Biol Chem
. 2011 Sep;
286(48):41745-41757.
PMID: 21956104
In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and...
7.
Wen K, McKane M, Stokasimov E, Fields J, Rubenstein P
J Biol Chem
. 2010 May;
285(27):21185-94.
PMID: 20442407
Intramolecular allosteric interactions responsible for actin conformational regulation are largely unknown. Previous work demonstrated that replacing yeast actin Val-76 with muscle actin Ile caused decreased nucleotide exchange. Residue 76 abuts...
8.
Stokasimov E, Rubenstein P
J Biol Chem
. 2009 Jul;
284(37):25421-30.
PMID: 19605362
Actin can exist in multiple conformations necessary for normal function. Actin isoforms, although highly conserved in sequence, exhibit different biochemical properties and cellular roles. We used amide proton hydrogen/deuterium (HD)...
9.
Stokasimov E, McKane M, Rubenstein P
J Biol Chem
. 2008 Oct;
283(50):34844-54.
PMID: 18945676
Filament formation is required for most of the functions of actin. However, the intermonomer interactions that stabilize F-actin have not been elucidated because of a lack of an F-actin crystal...