Els M A van de Westerlo
Overview
Explore the profile of Els M A van de Westerlo including associated specialties, affiliations and a list of published articles.
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16
Citations
301
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Recent Articles
1.
Bergmans J, van de Westerlo E, Grefte S, Adjobo-Hermans M, Koopman W
Methods Mol Biol
. 2024 Nov;
2878():223-232.
PMID: 39546265
Mitochondrial morphology and membrane potential (Δψ) are important readouts of mitochondrial function. Integrated analysis of these parameters in living cells can be performed using fluorescent lipophilic cations, which enter cells...
2.
Bulthuis E, Dieteren C, Bergmans J, Berkhout J, Wagenaars J, van de Westerlo E, et al.
EMBO J
. 2023 Feb;
42(7):e108533.
PMID: 36825437
Macromolecules of various sizes induce crowding of the cellular environment. This crowding impacts on biochemical reactions by increasing solvent viscosity, decreasing the water-accessible volume and altering protein shape, function, and...
3.
Damen L, van de Westerlo E, Versteeg E, van Wessel T, Daamen W, van Kuppevelt T
Glycoconj J
. 2020 May;
37(4):445-455.
PMID: 32468289
Heparan sulfate (HS) is a linear polysaccharide with high structural diversity. Different HS epitopes have been detected and localized using single chain variable fragment (scFv) antibodies from a 'single pot'...
4.
van Kuppevelt T, Oosterhof A, Versteeg E, Podhumljak E, van de Westerlo E, Daamen W
Sci Rep
. 2017 Nov;
7(1):14785.
PMID: 29093576
Technologies to sequence nucleic acids/proteins are widely available, but straightforward methodologies to sequence complex polysaccharides are lacking. We here put forward a strategy to sequence glycosaminoglycans, long linear polysaccharides involved...
5.
Holley R, Smith R, van de Westerlo E, Pickford C, Merry C, van Kuppevelt T
Methods Mol Biol
. 2014 Oct;
1229:239-51.
PMID: 25325958
The ability to characterize alterations in heparan sulfate (HS) structure during development or as a result of loss or mutation of one or more components of the HS biosynthetic pathway...
6.
van Wijk X, Oosterhof A, Versteeg E, van de Westerlo E, van Kuppevelt T
Biochem J
. 2014 May;
461(3):461-8.
PMID: 24819558
HS (heparan sulfate) is a long linear polysaccharide, variably modified by epimerization and sulfation reactions, and is organized into different domains defined by the extent of modification. To further elucidate...
7.
Houben A, van Wijk X, van Meeteren L, van Zeijl L, van de Westerlo E, Hausmann J, et al.
J Biol Chem
. 2012 Nov;
288(1):510-9.
PMID: 23150666
Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), playing a key role in diverse physiological and pathological processes. ATX exists in distinct splice...
8.
Thompson S, Fernig D, Jesudason E, Losty P, van de Westerlo E, van Kuppevelt T, et al.
J Biol Chem
. 2009 Oct;
284(51):35621-31.
PMID: 19837661
Heparan sulfate (HS) binds and modulates the transport and activity of a large repertoire of regulatory proteins. The HS phage display antibodies are powerful tools for the analysis of native...
9.
Ten Dam G, Yamada S, Kobayashi F, Purushothaman A, van de Westerlo E, Bulten J, et al.
Histochem Cell Biol
. 2009 Apr;
132(1):117-27.
PMID: 19360434
Dermatan sulfate (DS) expression in normal tissue and ovarian cancer was investigated using the novel, phage display-derived antibody GD3A12 that was selected against embryonic glycosaminoglycans (GAGs). Antibody GD3A12 was especially...
10.
Ten Dam G, van de Westerlo E, Purushothaman A, Stan R, Bulten J, Sweep F, et al.
Am J Pathol
. 2007 Aug;
171(4):1324-33.
PMID: 17717144
Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS modifications might be potential targets to influence tumor development. We applied the phage display technology to select...