Eloise Keeling
Overview
Explore the profile of Eloise Keeling including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
152
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0
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Recent Articles
1.
Lizama B, Keeling E, Cho E, Malagise E, Knezovich N, Waybright L, et al.
Sci Rep
. 2025 Feb;
15(1):4256.
PMID: 39929889
Trafficking defects in retinal pigmented epithelial (RPE) cells contribute to RPE atrophy, a hallmark of geographic atrophy (GA) in dry age-related macular degeneration (AMD). Dry AMD pathogenesis is multifactorial, including...
2.
Sanchez-Bretano A, Keeling E, Scott J, Lynn S, Soundara-Pandi S, Macdonald S, et al.
Sci Rep
. 2023 Oct;
13(1):17173.
PMID: 37821525
L-DOPA is deficient in the developing albino eye, resulting in abnormalities of retinal development and visual impairment. Ongoing retinal development after birth has also been demonstrated in the developing albino...
3.
Keeling E, Lynn S, Koh Y, Scott J, Kendall A, Gatherer M, et al.
Mol Nutr Food Res
. 2022 Mar;
66(11):e2100823.
PMID: 35306732
Scope: The intake of a "Western-style" diet rich in fats is linked with developing retinopathies including age-related macular degeneration (AMD). Wildtype mice are given a high fat diet (HFD) to...
4.
Ratnayaka J, Keeling E
Neural Regen Res
. 2021 Aug;
17(3):569-571.
PMID: 34380894
No abstract available.
5.
Lynn S, Johnston D, Scott J, Munday R, Desai R, Keeling E, et al.
Cells
. 2021 Mar;
10(2).
PMID: 33671133
Alzheimer's disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration (AMD) patients. To study Aβ-induced retinopathy, wild-type mice were...
6.
Keeling E, Chatelet D, Tan N, Khan F, Richards R, Thisainathan T, et al.
Int J Mol Sci
. 2020 Nov;
21(21).
PMID: 33182490
The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid, and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying photoreceptors in...
7.
Keeling E, Culling A, Johnston D, Chatelet D, Page A, Tumbarello D, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32932802
Impaired cargo trafficking and the aggregation of intracellular macromolecules are key features of neurodegeneration, and a hallmark of aged as well as diseased retinal pigment epithelial (RPE) cells in the...
8.
Ibbett P, Goverdhan S, Pipi E, Chouhan J, Keeling E, Angus E, et al.
Sci Rep
. 2019 May;
9(1):7475.
PMID: 31097765
Early stages of geographic atrophy (GA) age-related macular degeneration is characterised by the demise of photoreceptors, which precedes the loss of underlying retinal pigment epithelial (RPE) cells. Sight-loss due to...
9.
Ratnayaka J, Keeling E, Chatelet D
Methods Mol Biol
. 2019 Apr;
2150:167-182.
PMID: 30969403
The transport and targeting of internalized molecules to distinct intracellular organelles/compartments can prove challenging to visualize clearly, which can contribute to some of the difficulties associated with these studies. By...
10.
Keeling E, Chatelet D, Johnston D, Page A, Tumbarello D, Lotery A, et al.
Mol Nutr Food Res
. 2019 Mar;
63(15):e1800951.
PMID: 30835933
Scope: Oxidative stress and dysregulated intracellular trafficking are associated with an unhealthy diet which underlies pathology. Here, these effects on photoreceptor outer segment (POS) trafficking in the retinal pigment epithelium...