Elliott M Bernard
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Explore the profile of Elliott M Bernard including associated specialties, affiliations and a list of published articles.
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14
Citations
327
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Recent Articles
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Fattinger S, Maurer L, Geiser P, Bernard E, Enz U, Ganguillet S, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2315503120.
PMID: 37988464
Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores are hallmarks of a specific form of cell death...
3.
Pellegrino E, Aylan B, Bussi C, Fearns A, Bernard E, Athanasiadi N, et al.
J Cell Biol
. 2023 Sep;
222(12).
PMID: 37737955
Peroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial...
4.
Bernard E, Broz P
Mol Cell
. 2023 Aug;
83(15):2621-2623.
PMID: 37541218
Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al. implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell...
5.
Aylan B, Bernard E, Pellegrino E, Botella L, Fearns A, Athanasiadi N, et al.
Nat Microbiol
. 2023 Mar;
8(5):803-818.
PMID: 36959508
Autophagy is a cellular innate-immune defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non-canonical autophagy function to control Mtb infection in phagosomes and the cytosol remains...
6.
Bedard M, Niet S, Bernard E, Babunovic G, Cheng T, Aylan B, et al.
J Clin Invest
. 2023 Feb;
133(6).
PMID: 36757797
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche....
7.
Bussi C, Heunis T, Pellegrino E, Bernard E, Bah N, Silva Dos Santos M, et al.
Nat Commun
. 2022 Nov;
13(1):7338.
PMID: 36443305
Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic...
8.
Bernard E, Broz P
Biochem J
. 2022 Apr;
479(7):867-882.
PMID: 35438136
Following detection of pathogen infection and disrupted cellular homeostasis, cells can activate a range of cell death pathways, such as apoptosis, necroptosis and pyroptosis, as part of their defence strategy....
9.
Santucci P, Aylan B, Botella L, Bernard E, Bussi C, Pellegrino E, et al.
mBio
. 2022 Mar;
13(2):e0011722.
PMID: 35323041
Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy. However, it remains unclear whether fluctuating intracellular...
10.
Bernard E, Fearns A, Bussi C, Santucci P, Peddie C, Lai R, et al.
J Cell Sci
. 2020 Sep;
134(5).
PMID: 32938685
Xenophagy is an important cellular defence mechanism against cytosol-invading pathogens, such as (Mtb). Activation of xenophagy in macrophages targets Mtb to autophagosomes; however, how Mtb is targeted to autophagosomes in...