Antony Fearns
Overview
Explore the profile of Antony Fearns including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
493
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Recent Articles
1.
Prashar A, Bussi C, Fearns A, Capurro M, Gao X, Sesaki H, et al.
Nature
. 2024 Aug;
632(8027):1110-1117.
PMID: 39169179
Mitochondrial membranes define distinct structural and functional compartments. Cristae of the inner mitochondrial membrane (IMM) function as independent bioenergetic units that undergo rapid and transient remodelling, but the significance of...
2.
Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, et al.
Nature
. 2023 Nov;
624(7990):E3.
PMID: 37993723
No abstract available.
3.
Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, et al.
Nature
. 2023 Nov;
623(7989):1062-1069.
PMID: 37968398
Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells. To cope with this threat, cells possess mechanisms that repair the damage and restore cellular homeostasis. Endomembrane...
4.
Pellegrino E, Aylan B, Bussi C, Fearns A, Bernard E, Athanasiadi N, et al.
J Cell Biol
. 2023 Sep;
222(12).
PMID: 37737955
Peroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial...
5.
Aylan B, Bernard E, Pellegrino E, Botella L, Fearns A, Athanasiadi N, et al.
Nat Microbiol
. 2023 Mar;
8(5):803-818.
PMID: 36959508
Autophagy is a cellular innate-immune defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non-canonical autophagy function to control Mtb infection in phagosomes and the cytosol remains...
6.
Bussi C, Heunis T, Pellegrino E, Bernard E, Bah N, Silva Dos Santos M, et al.
Nat Commun
. 2022 Nov;
13(1):7338.
PMID: 36443305
Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic...
7.
Santucci P, Greenwood D, Fearns A, Chen K, Jiang H, Gutierrez M
Nat Commun
. 2021 Jun;
12(1):3816.
PMID: 34155215
To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments affect antibiotic accumulation and efficacy remains unclear. Here,...
8.
Queval C, Fearns A, Botella L, Smyth A, Schnettger L, Mitermite M, et al.
PLoS Pathog
. 2021 Mar;
17(3):e1009410.
PMID: 33720986
The Mycobacterium tuberculosis complex (MTBC) is a group of related pathogens that cause tuberculosis (TB) in mammals. MTBC species are distinguished by their ability to sustain in distinct host populations....
9.
Fearns A, Greenwood D, Rodgers A, Jiang H, Gutierrez M
PLoS Biol
. 2020 Dec;
18(12):e3000879.
PMID: 33382684
Correlative light, electron, and ion microscopy (CLEIM) offers huge potential to track the intracellular fate of antibiotics, with organelle-level resolution. However, a correlative approach that enables subcellular antibiotic visualisation in...
10.
Bernard E, Fearns A, Bussi C, Santucci P, Peddie C, Lai R, et al.
J Cell Sci
. 2020 Sep;
134(5).
PMID: 32938685
Xenophagy is an important cellular defence mechanism against cytosol-invading pathogens, such as (Mtb). Activation of xenophagy in macrophages targets Mtb to autophagosomes; however, how Mtb is targeted to autophagosomes in...