Ellen J Hess
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Explore the profile of Ellen J Hess including associated specialties, affiliations and a list of published articles.
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70
Citations
2009
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Recent Articles
1.
Roman K, Dinasarapu A, Cherian S, Fan X, Donsante Y, Aravind N, et al.
bioRxiv
. 2024 Oct;
PMID: 39415987
Striatal dysfunction is implicated in many forms of dystonia, including idiopathic, inherited and iatrogenic dystonias. The striatum is comprised largely of GABAergic spiny projection neurons (SPNs) that are defined by...
2.
Linen S, Chang N, Hess E, Stanley G, Waiblinger C
bioRxiv
. 2024 Jun;
PMID: 38895263
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta, leading to dopamine depletion in the striatum and the hallmark motor symptoms...
3.
Kilic-Berkmen G, Scorr L, McKay L, Thayani M, Donsante Y, Perlmutter J, et al.
Mov Disord Clin Pract
. 2024 May;
11(8):973-982.
PMID: 38778444
Background: Prior studies have indicated that female individuals outnumber male individuals for certain types of dystonia. Few studies have addressed factors impacting these sex differences or their potential biological mechanisms....
4.
Pan K, Jinnah H, Hess E, Smith Y, Villalba R
Eur J Neurosci
. 2023 Dec;
59(7):1407-1427.
PMID: 38123503
DYT1 dystonia is associated with decreased striatal dopamine release. In this study, we examined the possibility that ultrastructural changes of nigrostriatal dopamine terminals could contribute to this neurochemical imbalance using...
5.
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum
Roman K, Dinasarapu A, VanSchoiack A, Ross P, Kroeppler D, Jinnah H, et al.
Cell Rep
. 2023 Nov;
42(11):113435.
PMID: 37952158
The dorsal striatum is organized into functional territories defined by corticostriatal inputs onto both direct and indirect spiny projection neurons (SPNs), the major cell types within the striatum. In addition...
6.
Steel D, Reid K, Pisani A, Hess E, Fox S, Kurian M
Int Rev Neurobiol
. 2023 Jul;
169:217-258.
PMID: 37482394
Dystonia is characterised as uncontrolled, often painful involuntary muscle contractions that cause abnormal postures and repetitive or twisting movements. These movements can be continuous or sporadic and affect different parts...
7.
Roman K, Briscione M, Donsante Y, Ingram J, Fan X, Bernhard D, et al.
Neuroscience
. 2023 Mar;
517:37-49.
PMID: 36871883
Although the mechanisms underlying dystonia are largely unknown, dystonia is often associated with abnormal dopamine neurotransmission. DOPA-responsive dystonia (DRD) is a prototype disorder for understanding dopamine dysfunction in dystonia because...
8.
Downs A, Donsante Y, Jinnah H, Hess E
Neurobiol Dis
. 2022 Mar;
168:105699.
PMID: 35314320
Trihexyphenidyl (THP), a non-selective muscarinic receptor (mAChR) antagonist, is commonly used for the treatment of dystonia associated with TOR1A, otherwise known as DYT1 dystonia. A better understanding of the mechanism...
9.
Scarduzio M, Hess E, Standaert D, Eskow Jaunarajs K
Neurobiol Dis
. 2022 Feb;
166:105650.
PMID: 35139431
This review provides an overview of the synaptic dysfunctions of neuronal circuits and underlying neurochemical alterations observed in the hyperkinetic movement disorders, dystonia and dyskinesia. These disorders exhibit similar changes...
10.
Fagan M, Scorr L, Bernhardt D, Hess E, Perlmutter J, Pardo C, et al.
Exp Neurol
. 2021 Aug;
346:113855.
PMID: 34464652
Background: The dystonias are a group of disorders characterized by excessive muscle contractions leading to abnormal repetitive movements or postures. In blepharospasm, the face is affected, leading to excessive eye...