Anthony M Downs
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Explore the profile of Anthony M Downs including associated specialties, affiliations and a list of published articles.
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16
Citations
166
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Recent Articles
1.
Downs A, Kmiec G, Catavero C, McElligott Z
bioRxiv
. 2025 Jan;
PMID: 39868303
Tau pathology in the locus coeruleus (LC) is associated with several neurodegenerative conditions including Alzheimer's disease and frontotemporal dementia. Phosphorylated tau accumulates in the LC and results in inflammation, synaptic...
2.
Downs A, Kmiec G, McElligott Z
Addict Neurosci
. 2025 Jan;
13.
PMID: 39742087
The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the...
3.
Kelberman M, Rodberg E, Arabzadeh E, Bair-Marshall C, Berridge C, Berrocoso E, et al.
bioRxiv
. 2024 Oct;
PMID: 39464004
The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as autonomic systems, the...
4.
Downs A, Kmiec G, McElligott Z
bioRxiv
. 2023 Dec;
PMID: 38076868
The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the...
5.
Roman K, Briscione M, Donsante Y, Ingram J, Fan X, Bernhard D, et al.
Neuroscience
. 2023 Mar;
517:37-49.
PMID: 36871883
Although the mechanisms underlying dystonia are largely unknown, dystonia is often associated with abnormal dopamine neurotransmission. DOPA-responsive dystonia (DRD) is a prototype disorder for understanding dopamine dysfunction in dystonia because...
6.
Pati D, Downs A, McElligott Z, Kash T
J Neurosci
. 2022 Dec;
43(5):709-721.
PMID: 36526372
The bed nucleus of the stria terminalis (BNST) is a component of the extended amygdala that regulates motivated behavior and affective states and plays an integral role in the development...
7.
Downs A, Catavero C, Kasten M, McElligott Z
Alcohol
. 2022 Sep;
107:97-107.
PMID: 36150608
Alcohol use disorder is a major public health concern in the United States. Recent work has suggested a link between chronic alcohol consumption and the development of tauopathy disorders, such...
8.
Downs A, Donsante Y, Jinnah H, Hess E
Neurobiol Dis
. 2022 Mar;
168:105699.
PMID: 35314320
Trihexyphenidyl (THP), a non-selective muscarinic receptor (mAChR) antagonist, is commonly used for the treatment of dystonia associated with TOR1A, otherwise known as DYT1 dystonia. A better understanding of the mechanism...
9.
Downs A, McElligott Z
Neuropharmacology
. 2022 Feb;
208:108997.
PMID: 35176286
The central noradrenergic system innervates almost all regions of the brain and, as such, is well positioned to modulate many neural circuits implicated in behaviors and physiology underlying substance use...
10.
Briscione M, Dinasarapu A, Bagchi P, Donsante Y, Roman K, Downs A, et al.
Mol Genet Metab
. 2021 Jun;
133(4):352-361.
PMID: 34092491
Dystonia is characterized by involuntary muscle contractions that cause debilitating twisting movements and postures. Although dysfunction of the basal ganglia, a brain region that mediates movement, is implicated in many...