Tiago Fleming Outeiro
Overview
Explore the profile of Tiago Fleming Outeiro including associated specialties, affiliations and a list of published articles.
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Articles
133
Citations
4209
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Recent Articles
1.
Laurent C, Poncet G, Herskovits T, Alves de Sousa R, Le Corre L, Al-Azzani M, et al.
ACS Chem Neurosci
. 2025 Feb;
PMID: 40009035
The protein DJ-1 appears to play a protective role in the development of Parkinson's disease (PD). Here, we show that endogenous neurotoxins of the 1,2,3,4-tetrahydroisoquinoline family (TIQs), formed upon reaction...
2.
Padovani A, Galli A, Bazzoli E, Tolassi C, Caratozzolo S, Gumina B, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14556.
PMID: 39992249
Introduction: Growing evidence suggests a connection between insulin resistance and apolipoprotein E (APOE) genotype in Alzheimer's disease (AD) pathogenesis, but the mechanisms are unclear. We examined effects of insulin resistance...
3.
Al-Azzani M, Weber S, Ramalingam N, Ramon M, Shvachiy L, Mestre G, et al.
medRxiv
. 2025 Feb;
PMID: 39990587
Mutations and multiplications in the SNCA , encoding alpha-synuclein (aSyn), are associated with familial forms of Parkinson's disease (PD). We report the identification of a novel missense mutation (NM_000345.4, cDNA...
4.
Outeiro T, Hoglinger G, Lang A, Vieira T
J Neural Transm (Vienna)
. 2025 Feb;
PMID: 39932548
Protein misfolding and aggregation is a major pathological hallmark in a variety of human conditions, including cancer, diabetes, and neurodegeneration. However, we still do not fully understand the role of...
5.
Lang A, Hoglinger G, Adler C, Berg D, Klein C, Outeiro T, et al.
Alzheimers Dement
. 2024 Dec;
21(2):e14449.
PMID: 39732512
No abstract available.
6.
da Silva I, Cardoso A, Reimer L, Konig A, van Riesen C, Outeiro T, et al.
Biosens Bioelectron
. 2024 Nov;
268:116880.
PMID: 39509995
Aggregation of alpha-synuclein (aSyn) occurs in presynaptic neurons and constitutes a key factor for the progression of Parkinson's disease, emphasising the urgency of early detection to support effective treatment. Unfortunately,...
7.
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features
Brucke C, Al-Azzani M, Ramalingam N, Ramon M, Sousa R, Buratti F, et al.
medRxiv
. 2024 Oct;
PMID: 39399048
Background: Parkinson's disease (PD) affects millions of people worldwide, but only 5-10% of patients suffer from a monogenic form of the disease with Mendelian inheritance. , the gene encoding for...
8.
Dominguez-Meijide A, Vasili E, Outeiro T
Brain Sci
. 2024 Sep;
14(9).
PMID: 39335445
There was an error in the original publication [...].
9.
Fonseca-Fonseca L, Fuentes N, Sanchez J, Iglesias A, Outeiro T, da Silva V, et al.
Behav Brain Res
. 2024 Sep;
476:115269.
PMID: 39313072
We previously demonstrated that JM-20, a molecule with neuroactive functions, protects rats against rotenone and 6-hydroxydopamine (6-OHDA) neurotoxicity. In addition, we demonstrated that JM-20 inhibits the aggregation and cytotoxicity of...
10.
Soares E, Queiroz L, Gerhardt E, Prediger R, Outeiro T, Cimarosti H
Mol Cell Neurosci
. 2024 Sep;
131:103969.
PMID: 39260456
SUMOylation is a post-translational modification essential for various biological processes. SUMO proteins bind to target substrates in a three-step enzymatic pathway, which is rapidly reversible by the action of specific...