Elke Brotz
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Explore the profile of Elke Brotz including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
145
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Recent Articles
1.
Ahmed Y, Rebets Y, Tokovenko B, Brotz E, Luzhetskyy A
Sci Rep
. 2017 Aug;
7(1):9784.
PMID: 28852167
A large majority of genome-encrypted chemical diversity in actinobacteria remains to be discovered, which is related to the low level of secondary metabolism genes expression. Here, we report the application...
2.
Myronovskyi M, Brotz E, Rosenkranzer B, Manderscheid N, Tokovenko B, Rebets Y, et al.
Appl Microbiol Biotechnol
. 2016 Jul;
100(21):9175-9186.
PMID: 27412461
The biosynthetically well-studied landomycin A cluster has been used to demonstrate the unbalancing of gene transcription as an efficient method for the generation of new compounds. Landomycin A structural genes...
3.
Bilyk O, Brotz E, Tokovenko B, Bechthold A, Paululat T, Luzhetskyy A
ACS Chem Biol
. 2015 Nov;
11(1):241-50.
PMID: 26566170
Simocyclinone D8 (1, SD8) has attracted attention due to its highly complex hybrid structure and the unusual way it inhibits bacterial DNA gyrase by preventing DNA binding to the enzyme....
4.
Wardecki T, Brotz E, De Ford C, von Loewenich F, Rebets Y, Tokovenko B, et al.
Antonie Van Leeuwenhoek
. 2015 Jun;
108(2):391-402.
PMID: 26036671
Arnica montana L. is a medical plant of the Asteraceae family and grows preferably on nutrient poor soils in mountainous environments. Such surroundings are known to make plants dependent on...
5.
Maier S, Heitzler T, Asmus K, Brotz E, Hardter U, Hesselbach K, et al.
Chembiochem
. 2015 Apr;
16(8):1175-82.
PMID: 25907804
The biologically active compound mensacarcin is produced by Streptomyces bottropensis. The cosmid cos2 contains a large part of the mensacarcin biosynthesis gene cluster. Heterologous expression of this cosmid in Streptomyces...
6.
Rebets Y, Brotz E, Manderscheid N, Tokovenko B, Myronovskyi M, Metz P, et al.
Angew Chem Int Ed Engl
. 2014 Dec;
54(7):2280-4.
PMID: 25537663
Pamamycins are macrodiolides of polyketide origin with antibacterial activities. Their biosynthesis has been proposed to utilize succinate as a building block. However, the mechanism of succinate incorporation into a polyketide...
7.
Maier S, Pfluger T, Loesgen S, Asmus K, Brotz E, Paululat T, et al.
Chembiochem
. 2014 Feb;
15(5):749-56.
PMID: 24554499
Mensacarcin, a potential antitumour drug, is produced by Streptomyces bottropensis. The structure consists of a three-membered ring system with many oxygen atoms. Of vital importance in this context is an...
8.
Myronovskyi M, Tokovenko B, Brotz E, Ruckert C, Kalinowski J, Luzhetskyy A
Appl Microbiol Biotechnol
. 2013 Dec;
98(2):795-806.
PMID: 24337397
Streptomyces albus J1074 is a derivative of the S. albus G1 strain defective in SalG1 restriction-modification system. Genome sequencing of S. albus J1074 revealed that the size of its chromosome...
9.
Rebets Y, Brotz E, Tokovenko B, Luzhetskyy A
J Ind Microbiol Biotechnol
. 2013 Oct;
41(2):387-402.
PMID: 24127068
Actinomycetes genome sequencing and bioinformatic analyses revealed a large number of "cryptic" gene clusters coding for secondary metabolism. These gene clusters have the potential to increase the chemical diversity of...
10.
Strobel T, Schmidt Y, Linnenbrink A, Luzhetskyy A, Luzhetska M, Taguchi T, et al.
Appl Environ Microbiol
. 2013 Jun;
79(17):5224-32.
PMID: 23793643
Saccharothrix espanaensis is a member of the order Actinomycetales. The genome of the strain has been sequenced recently, revealing 106 glycosyltransferase genes. In this paper, we report the detection of...