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Andreas Bechthold

Explore the profile of Andreas Bechthold including associated specialties, affiliations and a list of published articles. Areas
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Articles 138
Citations 1952
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Recent Articles
1.
Latta O, Weinert E, Bechthold A
J Inorg Biochem . 2025 Mar; 269:112874. PMID: 40056506
Streptomyces species are vital for producing natural products like antibiotics, with c-di-GMP playing a key role in regulating processes such as differentiation. C-di-GMP metabolism is controlled by diguanylate cyclases (DGCs)...
2.
Muller M, Bialas E, Sturm I, Sood U, Lal R, Bechthold A
Front Antibiot . 2025 Jan; 3():1399139. PMID: 39816246
Rifamycin and its derivatives are natural products that belong to the class of antibiotic-active polyketides and have significant therapeutic relevance within the therapy scheme of tuberculosis, a worldwide infectious disease...
3.
Makitrynskyy R, Keller L, Kaur A, Tsypik O, Munz L, Bechthold A, et al.
Chemistry . 2024 Dec; 31(8):e202403985. PMID: 39620272
Research into new antibiotics is becoming increasingly important as antibiotic resistance increases worldwide. The genus Streptomyces in particular is able to produce a wide range of antimicrobial products due to...
4.
Yu D, Lin H, Bechthold A, Yu X, Ma Z
Int J Biol Macromol . 2024 Nov; 285:138043. PMID: 39592035
The TetR family of regulators (TFRs), commonly reported as repressors, plays a role in regulating secondary metabolite production in Streptomyces. In this study, we sought to elucidate the relationship between...
5.
Hollands S, Tasch J, Simon D, Wassouf D, Barber I, Gessner A, et al.
Chem Sci . 2024 Nov; 15(47):19858-19869. PMID: 39568915
Curacozole is representative of a cyanobactin-like sub-family of ribosomally synthesized and post-translationally modified peptides (RiPPs). The molecule is distinguished by its small macrocyclic structure, a poly-azole sequence that includes a...
6.
Sood U, Muller M, Lan T, Garg G, Singhvi N, Hira P, et al.
J Nat Prod . 2024 Jan; 87(2):424-438. PMID: 38289177
Ever since the isolation of in 1957, this strain has been the focus of research worldwide. In the last 60 years or more, our understanding of the taxonomy, development of...
7.
Bao H, Li H, Zhang Y, Bechthold A, Yu X, Ma Z
World J Microbiol Biotechnol . 2023 Oct; 39(12):359. PMID: 37891332
The transposon mutagenesis strategy has been employed to generate random insertion mutants and analyze the correlation between genes and secondary metabolites in the genus Streptomyces. In this study, our primary...
8.
Zhang S, Zhang L, Greule A, Tailhades J, Marschall E, Prasongpholchai P, et al.
Acta Pharm Sin B . 2023 Sep; 13(8):3561-3574. PMID: 37655329
WS9326A is a peptide antibiotic containing a highly unusual -methyl--2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by (P450)...
9.
Li H, Hu Y, Zhang Y, Ma Z, Bechthold A, Yu X
Microb Cell Fact . 2023 Feb; 22(1):32. PMID: 36810073
Background: Streoptomyces rimosus M527 is a producer of the polyene macrolide rimocidin which shows activity against various plant pathogenic fungi. Notably, the regulatory mechanisms underlying rimocidin biosynthesis are yet to...
10.
Shi Y, Zhang J, Ma Z, Zhang Y, Bechthold A, Yu X
Biotechnol Bioeng . 2023 Feb; 120(5):1411-1422. PMID: 36775891
In Streptomyces rimosus M527, the oxytetracycline (OTC) biosynthetic gene cluster is not expressed under laboratory conditions. In this study a reported-guided mutant selection (RGMS) procedure was used to activate the...