Elizabeth A Williamson
Overview
Explore the profile of Elizabeth A Williamson including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
1934
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Recent Articles
1.
Agrawal R, Al-Hiyari S, Hugh-White R, Hromas R, Patel Y, Williamson E, et al.
Eur Urol Oncol
. 2024 Nov;
PMID: 39547899
Background And Objective: The etiology of prostate cancer (PC) is multifactorial and poorly understood. It has been suggested that colibactin-producing Escherichia coli positive for the pathogenicity island pks (pks) initiate...
2.
Nickoloff J, Jaiswal A, Sharma N, Williamson E, Tran M, Arris D, et al.
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38069223
Replicative DNA polymerases are blocked by nearly all types of DNA damage. The resulting DNA replication stress threatens genome stability. DNA replication stress is also caused by depletion of nucleotide...
3.
Jaiswal A, Dutta A, Srinivasan G, Yuan Y, Zhou D, Shaheen M, et al.
Nucleic Acids Res
. 2023 Nov;
51(22):12224-12241.
PMID: 37953292
BRCA1-deficient cells have increased IRE1 RNase, which degrades multiple microRNAs. Reconstituting expression of one of these, miR-4638-5p, resulted in synthetic lethality in BRCA1-deficient cancer cells. We found that miR-4638-5p represses...
4.
Chen S, Srinivasan G, Jaiswal A, Williamson E, Li L, Arris D, et al.
Exp Hematol
. 2023 Oct;
129:104123.
PMID: 37875176
When hematopoietic cells are overwhelmed with ionizing radiation (IR) DNA damage, the alternative non-homologous end-joining (aNHEJ) repair pathway is activated to repair stressed replication forks. While aNHEJ can rescue cells...
5.
Jaiswal A, Williamson E, Jaiswal A, Kong K, Hromas R
Methods Mol Biol
. 2023 Aug;
2701:91-112.
PMID: 37574477
The mammalian cell genome is continuously exposed to endogenous and exogenous insults that modify its DNA. These modifications can be single-base lesions, bulky DNA adducts, base dimers, base alkylation, cytosine...
6.
Jaiswal A, Kim H, Scharer O, Sharma N, Williamson E, Srinivasan G, et al.
NAR Cancer
. 2023 Jan;
5(1):zcac044.
PMID: 36683914
Unrepaired oxidatively-stressed replication forks can lead to chromosomal instability and neoplastic transformation or cell death. To meet these challenges cells have evolved a robust mechanism to repair oxidative genomic DNA...
7.
Hromas R, Srinivasan G, Yang M, Jaiswal A, Totterdale T, Phillips L, et al.
iScience
. 2022 Dec;
25(12):105626.
PMID: 36471805
Tumors with mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks. One such...
8.
Jaiswal A, Jaiswal A, Williamson E, Gelfond J, Zheng G, Zhou D, et al.
Cancer Chemother Pharmacol
. 2022 Nov;
91(1):89-95.
PMID: 36346454
Purpose: The BCL-2 family of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1, can mediate survival of some types of cancer. DT2216 is a PROteolysis-TArgeting Chimera (PROTAC) that degrades BCL-XL specifically and...
9.
Reuter K, Andriantsaralaza S, Hansen M, LaFleur M, Jerusalinsky L, Louis E, et al.
Animals (Basel)
. 2022 May;
12(9).
PMID: 35565640
There is evidence to suggest that the Coronavirus Disease 2019 (COVID-19) pandemic may hamper our achievement of the Sustainable Development Goals (SDGs). Here, we use non-human primates as a case...
10.
Marsh C, Sica Y, Burgin C, Dorman W, Anderson R, Del Toro Mijares I, et al.
J Biogeogr
. 2022 May;
49(5):979-992.
PMID: 35506011
Aim: Comprehensive, global information on species' occurrences is an essential biodiversity variable and central to a range of applications in ecology, evolution, biogeography and conservation. Expert range maps often represent...