Elizabeth A Eckman
Overview
Explore the profile of Elizabeth A Eckman including associated specialties, affiliations and a list of published articles.
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22
Citations
1553
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Recent Articles
1.
Eckman E, Clausen D, Sole-Domenech S, Lee C, Sinobas-Pereira C, Domalewski R, et al.
J Neurosci
. 2023 Oct;
43(50):8812-8824.
PMID: 37884349
Accumulation of amyloid-β peptide (Aβ) aggregates in synapses may contribute to the profound synaptic loss characteristic of Alzheimer's disease (AD). The origin of synaptic Aβ aggregates remains elusive, but loss...
2.
Herdt A, Peng H, Dickson D, Golde T, Eckman E, Lee C
Genes (Basel)
. 2023 Aug;
14(8).
PMID: 37628569
Krabbe disease (KD) is a progressive and devasting neurological disorder that leads to the toxic accumulation of psychosine in the white matter of the central nervous system (CNS). The condition...
3.
Perez-Gonzalez R, Kim Y, Miller C, Pacheco-Quinto J, Eckman E, Levy E
FASEB J
. 2020 Aug;
34(9):12922-12931.
PMID: 32772431
Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the...
4.
Eckman E, Clausen D, Herdt A, Pacheco-Quinto J, Halperin J
Clin Infect Dis
. 2020 Mar;
72(10):1719-1726.
PMID: 32221538
Background: Demonstration of intrathecal production of Borrelia-specific antibodies (ITAb) is considered the most specific diagnostic marker of Lyme neuroborreliosis (LNB). Limitations include delayed detectability in early infection and continued presence...
5.
Pacheco-Quinto J, Clausen D, Perez-Gonzalez R, Peng H, Meszaros A, Eckman C, et al.
FASEB J
. 2018 Nov;
33(3):3758-3771.
PMID: 30481490
Accumulating evidence suggests that the abnormal aggregation of amyloid-β (Αβ) peptide in Alzheimer's disease (AD) begins intraneuronally, within vesicles of the endosomal-lysosomal pathway where Aβ is both generated and degraded....
6.
Eckman E, Pacheco-Quinto J, Herdt A, Halperin J
Clin Infect Dis
. 2018 Jan;
67(1):80-88.
PMID: 29340592
Background: Lyme encephalopathy, characterized by nonspecific neurobehavioral symptoms including mild cognitive difficulties, may occur in patients with systemic Lyme disease and is often mistakenly attributed to central nervous system (CNS)...
7.
Pacheco-Quinto J, Eckman C, Eckman E
Neurobiol Aging
. 2016 Sep;
48:83-92.
PMID: 27644077
Impaired clearance of amyloid-β peptide (Aβ) has been postulated to significantly contribute to the amyloid accumulation typical of Alzheimer's disease. Among the enzymes known to degrade Aβ in vivo are...
8.
Pacheco-Quinto J, Eckman E
J Biol Chem
. 2013 Jan;
288(8):5606-15.
PMID: 23283972
Impairments in Aβ removal are increasingly being considered as a possible cause for the abnormal Aβ build-up typical of Alzheimer disease. Of particular interest is a pool of Aβ that...
9.
Pacheco-Quinto J, Herdt A, Eckman C, Eckman E
J Alzheimers Dis
. 2012 Aug;
33 Suppl 1:S101-10.
PMID: 22903130
The efficient clearance of amyloid-β (Aβ) is essential to modulate levels of the peptide in the brain and to prevent it from accumulating in senile plaques, a hallmark of Alzheimer's...
10.
Suh J, Lyckman A, Wang L, Eckman E, Guenette S
J Neurochem
. 2011 Aug;
119(2):377-88.
PMID: 21824144
Amyloid precursor protein (APP) family members and their proteolytic products are implicated in normal nervous system function and Alzheimer's disease pathogenesis. APP processing and Aβ secretion are regulated by neuronal...