Elisabetta Groaz
Overview
Explore the profile of Elisabetta Groaz including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
158
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Recent Articles
1.
Katopodi V, Marino A, Pateraki N, Verheyden Y, Cinque S, Jimenez E, et al.
Cell Death Differ
. 2024 Sep;
32(3):397-415.
PMID: 39294440
Upregulation of mitochondrial respiration coupled with high ROS-scavenging capacity is a characteristic shared by drug-tolerant cells in several cancers. As translational fidelity is essential for cell fitness, protection of the...
2.
Groaz E, Modranka J, Ploschik D, Jabgunde A, Froeyen M, Jang M, et al.
Bioorg Chem
. 2024 Jun;
150:107600.
PMID: 38945086
In this study, we investigated how the replacement of the tetrahydrothiophene ring of biotin with either an oxolane or (methyl)pyrrolidine moiety may affect its molecular interactions, in an effort to...
3.
Rodriguez-Robles E, Muller D, Kunzl T, Nemat S, Edelmann M, Srivastava P, et al.
Metab Eng
. 2024 May;
85:26-34.
PMID: 38802041
Integration of novel compounds into biological processes holds significant potential for modifying or expanding existing cellular functions. However, the cellular uptake of these compounds is often hindered by selectively permeable...
4.
Li X, Groaz E, Herdewijn P, Lescrinier E
Chemistry
. 2024 Apr;
30(37):e202401254.
PMID: 38687344
An acyclic phosphonate-linked nucleic acid backbone (ZNA) demonstrated the capability to support duplex formation and propagate genetic information in vivo, unveiling its potential for evolution into a synthetic genetic system...
5.
Ghezzo M, Grigoletto L, Rigo R, Herdewijn P, Groaz E, Sissi C
Biochimie
. 2023 Aug;
214(Pt A):112-122.
PMID: 37558081
I-motifs are non-canonical DNA structures consisting of two parallel strands held together by hemiprotonated cytosine-cytosine base pairs, which intercalate to form a ordered column of stacked base pairs. This unique...
6.
Martina M, Giammarino F, Vicenti I, Groaz E, Rozenski J, Incerti M, et al.
ChemMedChem
. 2023 May;
18(16):e202300200.
PMID: 37221137
The plethora of viral outbreaks experienced in the last decade, together with the widespread distribution of many re-emerging and newly emerging viruses, emphasize the urgent need for novel broad-spectrum antivirals...
7.
Xu Y, Groaz E, Rihon J, Herdewijn P, Lescrinier E
Eur J Med Chem
. 2023 Apr;
255:115379.
PMID: 37120998
Molecular dynamics (MD) simulations provided insights into the favorable interactions between xylose nucleosides bearing a phosphonate moiety at their 3'-position and specific residues at the active site of the archetypal...
8.
Yang H, Eremeeva E, Abramov M, Jacquemyn M, Groaz E, Daelemans D, et al.
Nucleic Acids Res
. 2023 Jan;
51(4):1501-1511.
PMID: 36611237
An enzymatic method has been successfully established enabling the generation of partially base-modified RNA (previously named RZA) constructs, in which all G residues were replaced by isomorphic fluorescent thienoguanosine (thG)...
9.
Stevaert A, Groaz E, Naesens L
Curr Opin Virol
. 2022 Nov;
57:101279.
PMID: 36403338
The COVID-19 pandemic has accelerated the development of nucleoside analogs to treat respiratory virus infections, with remdesivir being the first compound to receive worldwide authorization and three other nucleoside analogs...
10.
Goulding L, Kiss E, Vrancken R, Goris N, Luo M, Groaz E, et al.
mSphere
. 2022 Nov;
7(6):e0037822.
PMID: 36317894
African swine fever virus (ASFV) causes a highly contagious hemorrhagic disease with case fatality rates approaching 100% in domestic pigs. ASFV is responsible for substantial economic losses, but despite ongoing...