Elisabeth Ehler
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Explore the profile of Elisabeth Ehler including associated specialties, affiliations and a list of published articles.
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110
Citations
3226
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Recent Articles
1.
Li C, Warren D, Zhou C, De Silva S, Wilson D, Garcia-Maya M, et al.
J Biol Chem
. 2024 Apr;
300(5):107254.
PMID: 38569934
Nesprins comprise a family of multi-isomeric scaffolding proteins, forming the linker of nucleoskeleton-and-cytoskeleton complex with lamin A/C, emerin and SUN1/2 at the nuclear envelope. Mutations in nesprin-1/-2 are associated with...
2.
Ormrod B, Ehler E
Biophys Rev
. 2024 Jan;
15(6):1941-1950.
PMID: 38192353
Cardiomyocytes that are derived from human-induced pluripotent stem cells (iPSC-CM) are an exciting tool to investigate cardiomyopathy disease mechanisms at the cellular level as well as to screen for potential...
3.
Pearce A, Ponnam S, Holt M, Randall T, Beckingham R, Kho A, et al.
J Biol Chem
. 2023 Dec;
300(1):105511.
PMID: 38042491
Myosin binding protein-C (MyBP-C) is a multidomain protein that regulates muscle contraction. Mutations in MYBPC3, the gene encoding for the cardiac variant (henceforth called cMyBP-C), are amongst the most frequent...
4.
Psefteli P, Morris J, Ehler E, Smith L, Bowe J, Mann G, et al.
Redox Biol
. 2023 Sep;
67:102883.
PMID: 37774548
In adverse pregnancy a perturbed redox environment is associated with abnormal early-life cardiovascular development and function. Previous studies have noted alterations in the expression and/or activity of Nuclear Factor E2...
5.
Dark N, Cosson M, Tsansizi L, Owen T, Ferraro E, Francis A, et al.
Cell Rep Methods
. 2023 May;
3(4):100456.
PMID: 37159667
Decreased left ventricle (LV) function caused by genetic mutations or injury often leads to debilitating and fatal cardiovascular disease. LV cardiomyocytes are, therefore, a potentially valuable therapeutical target. Human pluripotent...
6.
Chandler J, Treacy C, Ameer-Beg S, Ehler E, Irving M, Kampourakis T
Proc Natl Acad Sci U S A
. 2023 Mar;
120(12):e2222005120.
PMID: 36913580
Cardiac myosin binding protein-C (cMyBP-C) is a thick filament-associated regulatory protein frequently found mutated in patients suffering from hypertrophic cardiomyopathy (HCM). Recent in vitro experiments have highlighted the functional significance...
7.
Broadway-Stringer S, Jiang H, Wadmore K, Hooper C, Douglas G, Steeples V, et al.
Cells
. 2023 Mar;
12(5).
PMID: 36899856
Pathogenic variants in , coding for alpha-actinin 2, are known to be rare causes of Hypertrophic Cardiomyopathy. However, little is known about the underlying disease mechanisms. Adult heterozygous mice carrying...
8.
Stathopoulou K, Schnittger J, Raabe J, Fleischer F, Mangels N, Piasecki A, et al.
FEBS J
. 2022 Feb;
289(15):4622-4645.
PMID: 35176204
Four-and-a-half LIM domains protein 2 (FHL2) is an anti-hypertrophic adaptor protein that regulates cardiac myocyte signalling and function. Herein, we identified cardiomyopathy-associated 5 (CMYA5) as a novel FHL2 interaction partner...
9.
Appelt D, Ehler E, Shukla Mukherjee S, Heintzmann R, Wicker K
Philos Trans A Math Phys Eng Sci
. 2022 Feb;
380(2220):20210193.
PMID: 35152759
The need for acquiring at least three images to reconstruct an optical section of a sample limits the acquisition rate in structured illumination microscopy (SIM) for optical sectioning. In polarized...
10.