Elena Dobrovetsky
Overview
Explore the profile of Elena Dobrovetsky including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
400
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0
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Recent Articles
1.
Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless V, et al.
Bioorg Med Chem
. 2019 Jul;
27(17):3866-3878.
PMID: 31327677
SET domain bifurcated protein 1 (SETDB1) is a human histone-lysine methyltransferase which is amplified in human cancers and was shown to be crucial in the growth of non-small and small...
2.
Umit Kaniskan H, Eram M, Zhao K, Szewczyk M, Yang X, Schmidt K, et al.
J Med Chem
. 2017 Dec;
61(3):1204-1217.
PMID: 29244490
PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly...
3.
Huang R, Gorman K, Vinci C, Dobrovetsky E, Graslund S, Kay B
Int J Mol Sci
. 2015 Oct;
16(10):23587-603.
PMID: 26437402
Often when generating recombinant affinity reagents to a target, one singles out an individual binder, constructs a secondary library of variants, and affinity selects a tighter or more specific binder....
4.
Bezerra G, Dobrovetsky E, Seitova A, Fedosyuk S, Dhe-Paganon S, Gruber K
Sci Rep
. 2015 Mar;
5:8769.
PMID: 25740212
The voltage-gated potassium channel family (Kv) constitutes the most diverse class of ion channels in the nervous system. Dipeptidyl peptidase 10 (DPP10) is an inactive peptidase that modulates the electrophysiological...
5.
Umit Kaniskan H, Szewczyk M, Yu Z, Eram M, Yang X, Schmidt K, et al.
Angew Chem Int Ed Engl
. 2015 Mar;
54(17):5166-70.
PMID: 25728001
PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is essential for maturation of ribosomes, may have a role in lipogenesis, and is implicated in several diseases....
6.
Ferrara F, DAngelo S, Gaiotto T, Naranjo L, Tian H, Graslund S, et al.
MAbs
. 2014 Dec;
7(1):32-41.
PMID: 25530082
Only a small fraction of the antibodies in a traditional polyclonal antibody mixture recognize the target of interest, frequently resulting in undesirable polyreactivity. Here, we show that high-quality recombinant polyclonals,...
7.
Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, et al.
J Med Chem
. 2013 Mar;
56(5):2110-24.
PMID: 23445220
Protein arginine methyltransferases (PRMTs) play an important role in diverse biological processes. Among the nine known human PRMTs, PRMT3 has been implicated in ribosomal biosynthesis via asymmetric dimethylation of the...
8.
Bezerra G, Dobrovetsky E, Dong A, Seitova A, Crombett L, Shewchuk L, et al.
PLoS One
. 2012 Sep;
7(8):e43019.
PMID: 22952628
Proline-specific dipeptidyl peptidases (DPPs) are emerging targets for drug development. DPP4 inhibitors are approved in many countries, and other dipeptidyl peptidases are often referred to as DPP4 activity- and/or structure-homologues...
9.
Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney G, et al.
Structure
. 2012 Jul;
20(8):1425-35.
PMID: 22795084
PRMT3, a protein arginine methyltransferase, has been shown to influence ribosomal biosynthesis by catalyzing the dimethylation of the 40S ribosomal protein S2. Although PRMT3 has been reported to be a...
10.
Bezerra G, Dobrovetsky E, Viertlmayr R, Dong A, Binter A, Abramic M, et al.
Proc Natl Acad Sci U S A
. 2012 Apr;
109(17):6525-30.
PMID: 22493238
Opioid peptides are involved in various essential physiological processes, most notably nociception. Dipeptidyl peptidase III (DPP III) is one of the most important enkephalin-degrading enzymes associated with the mammalian pain...