Elena B Pasquale
Overview
Explore the profile of Elena B Pasquale including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
143
Citations
6986
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Koutouan E, Niibe A, Sample J, Carlson D, Graham R, Smoot R, et al.
bioRxiv
. 2025 Mar;
PMID: 40060438
EPHA2 is a receptor tyrosine kinase highly expressed in many cancers. By analyzing cancer patient databases for mutations in the EPHA2 coding sequence, we found that cholangiocarcinoma (a hepatobiliary cancer...
2.
Zapata-Mercado E, Rainwater R, Ozdemir E, Azarova E, Krzyscik M, Pasquale E, et al.
J Biol Chem
. 2025 Mar;
:108383.
PMID: 40049409
Biased signaling is the ability of a receptor to differentially activate certain signaling cascades in response to different ligands. Our previous work demonstrated that the monomeric ephrinA1 (m-ephrinA1) ligand and...
3.
Matsumoto M, Gomez-Soler M, Lombardi S, Lechtenberg B, Pasquale E
J Biol Chem
. 2024 Dec;
301(2):108099.
PMID: 39706267
Missense mutations in the EPHA1 receptor tyrosine kinase have been identified in Alzheimer's patients. To gain insight into their potential role in disease pathogenesis, we investigated the effects of four...
4.
Pasquale E
Trends Biochem Sci
. 2024 Nov;
49(12):1079-1096.
PMID: 39537538
Eph receptor tyrosine kinases, together with their cell surface-anchored ephrin ligands, constitute an important cell-cell communication system that regulates physiological and pathological processes in most cell types. This review focuses...
5.
Abdelazeem K, Nguyen D, Corbo S, Darragh L, Matsumoto M, Van Court B, et al.
Oncogene
. 2024 Nov;
44(3):130-146.
PMID: 39489818
The EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck...
6.
Corbo S, Nguyen D, Bhatia S, Darragh L, Abdelazeem K, Van Court B, et al.
bioRxiv
. 2024 Aug;
PMID: 39211197
Significance: EphA4 in regulatory T cells has a pro-tumoral effect while EphA4 in macrophages plays an anti-tumoral role underscoring the necessity of developing biologically rational therapeutics.
7.
Abdelazeem K, Nguyen D, Corbo S, Darragh L, Matsumoto M, Van Court B, et al.
bioRxiv
. 2024 Aug;
PMID: 39091728
The EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck...
8.
Wirth D, Ozdemir E, Wimley W, Pasquale E, Hristova K
J Biol Chem
. 2024 Jun;
300(7):107441.
PMID: 38838777
The transmembrane helices of receptor tyrosine kinases (RTKs) have been proposed to switch between two different dimeric conformations, one associated with the inactive RTK and the other with the active...
9.
Gomez-Soler M, Olson E, de la Torre E, Zhao C, Lamberto I, Flood D, et al.
Eur J Med Chem
. 2024 Mar;
262.
PMID: 38523699
The EphA4 receptor tyrosine kinase plays a role in neurodegenerative diseases, inhibition of nerve regeneration, cancer progression and other diseases. Therefore, EphA4 inhibition has potential therapeutic value. Selective EphA4 kinase...
10.
Sasine J, Kozlova N, Valicente L, Dukov J, Tran D, Himburg H, et al.
Cancer Res
. 2024 Jan;
84(6):919-934.
PMID: 38231476
Significance: Ephrin B2 reverse signaling mediated by endothelial cells directly regulates multiple myeloma progression and treatment resistance, which can be overcome through targeted inhibition of ephrin B2 to abolish myeloma.