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Ekaterina Spirova

Explore the profile of Ekaterina Spirova including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 14
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Recent Articles
1.
Kudryavtsev D, Isaeva A, Barkova D, Spirova E, Mukhutdinova R, Kasheverov I, et al.
Molecules . 2021 Mar; 26(5). PMID: 33652901
Slow-channel congenital myasthenic syndromes (SCCMSs) are rare genetic diseases caused by mutations in muscle nicotinic acetylcholine receptor (nAChR) subunits. Most of the known SCCMS-associated mutations localize at the transmembrane region...
2.
Manetti D, Garifulina A, Bartolucci G, Bazzicalupi C, Bellucci C, Chiaramonte N, et al.
J Med Chem . 2019 Jan; 62(4):1887-1901. PMID: 30681854
A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat...
3.
Shelukhina I, Spirova E, Kudryavtsev D, Ojomoko L, Werner M, Methfessel C, et al.
PLoS One . 2017 Aug; 12(8):e0181936. PMID: 28797116
Elucidation of the structural basis of pharmacological differences for highly homologous α7 and α9 nicotinic acetylcholine receptors (nAChRs) may shed light on their involvement in different physiological functions and diseases....
4.
Manetti D, Bellucci C, Dei S, Teodori E, Varani K, Spirova E, et al.
Eur J Med Chem . 2016 Feb; 110:246-58. PMID: 26840365
As a continuation of previous work on quinoline derivatives, which showed some preference (2-3 times) for the α7 with respect to α4β2 acetylcholine nicotinic receptors (nAChRs), we synthesized a series...