Eimear E Holohan
Overview
Explore the profile of Eimear E Holohan including associated specialties, affiliations and a list of published articles.
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8
Citations
497
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Recent Articles
1.
Sudhakaran I, Hillebrand J, Dervan A, Das S, Holohan E, Hulsmeier J, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
111(1):E99-E108.
PMID: 24344294
Fragile X mental retardation protein (FMRP) and Ataxin-2 (Atx2) are triplet expansion disease- and stress granule-associated proteins implicated in neuronal translational control and microRNA function. We show that Drosophila FMRP...
2.
Sudhakaran I, Holohan E, Osman S, Rodrigues V, VijayRaghavan K, Ramaswami M
J Neurosci
. 2012 May;
32(21):7225-31.
PMID: 22623667
Recurrent inhibition, wherein excitatory principal neurons stimulate inhibitory interneurons that feedback on the same principal cells, occurs ubiquitously in the brain. However, the regulation and function of recurrent inhibition are...
3.
McCann C, Holohan E, Das S, Dervan A, Larkin A, Lee J, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(36):E655-62.
PMID: 21795609
Local control of mRNA translation has been proposed as a mechanism for regulating synapse-specific plasticity associated with long-term memory. We show here that glomerulus-selective plasticity of Drosophila multiglomerular local interneurons...
4.
Das S, Sadanandappa M, Dervan A, Larkin A, Lee J, Sudhakaran I, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(36):E646-54.
PMID: 21795607
Despite its ubiquity and significance, behavioral habituation is poorly understood in terms of the underlying neural circuit mechanisms. Here, we present evidence that habituation arises from potentiation of inhibitory transmission...
5.
Cachero S, Simpson T, zur Lage P, Ma L, Newton F, Holohan E, et al.
PLoS Biol
. 2011 Feb;
9(1):e1000568.
PMID: 21283833
In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. Whilst the role of proneural factors in fate specification is well studied, the link between neural specification...
6.
Holohan E, Kwong C, Adryan B, Bartkuhn M, Herold M, Renkawitz R, et al.
PLoS Genet
. 2007 Jul;
3(7):e112.
PMID: 17616980
Insulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter interaction. The zinc-finger protein CTCF is well studied in vertebrates...
7.
Holohan E, zur Lage P, Jarman A
BMC Dev Biol
. 2006 Nov;
6:53.
PMID: 17094800
Background: The regulation of proneural gene expression is an important aspect of neurogenesis. In the study of the Drosophila proneural genes, scute and atonal, several themes have emerged that contribute...
8.
zur Lage P, Prentice D, Holohan E, Jarman A
Development
. 2003 Aug;
130(19):4683-93.
PMID: 12925594
Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first...