Eefjan Breukink
Overview
Explore the profile of Eefjan Breukink including associated specialties, affiliations and a list of published articles.
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130
Citations
4183
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Recent Articles
1.
Xie M, Derks M, Koch E, van Boven C, Janlad M, Bagheri B, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40041982
Membrane lipid oxidation is a universal process that occurs in situations of oxidative stress and is encountered in numerous physiological and pathological situations. Oxidized truncated phospholipids make up a large...
2.
Hernandez-Rocamora V, Martorana A, Belloso A, Ballesteros D, Zaccaria M, Perez A, et al.
bioRxiv
. 2025 Mar;
PMID: 40027703
Peptidoglycan hydrolases facilitate bacterial cell wall growth by creating space for insertion of new material and allowing physical separation of daughter cells. In , three peptidoglycan amidases, AmiA, AmiB and...
3.
Xie M, Koch E, van Walree C, Sobota A, Sonnen A, Killian J, et al.
Commun Biol
. 2024 Sep;
7(1):1161.
PMID: 39289481
Oxidative stress in combination with acid stress has been shown to inactivate a wide spectrum of microorganisms, including multi-resistant bacteria. This occurs e.g. in phagolysosomes or during treatment by cold...
4.
Kumar R, Breukink E, Weingarth M
Chembiochem
. 2024 Aug;
25(21):e202400543.
PMID: 39140470
Bacterial infections present a major global health threat, often displaying resistance to various antibiotics. Lipoteichoic acid (LTA) is a vital component of bacterial cell envelopes of Gram-positive bacteria, crucial for...
5.
van Aalst E, Yekefallah M, A M van Beekveld R, Breukink E, Weingarth M, Wylie B
J Struct Biol X
. 2024 Jun;
9:100101.
PMID: 38883399
Physical properties of biological membranes directly or indirectly govern biological processes. Yet, the interplay between membrane and integral membrane proteins is difficult to assess due to reciprocal effects between membrane...
6.
Jekhmane S, Derks M, Maity S, Slingerland C, Tehrani K, Medeiros-Silva J, et al.
Nat Microbiol
. 2024 May;
9(7):1778-1791.
PMID: 38783023
Antimicrobial resistance is a leading cause of mortality, calling for the development of new antibiotics. The fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks bacterial cell wall...
7.
Xu Y, Wang X, Zaal E, Berkers C, Lorent J, Heise T, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2024 Feb;
1869(4):159467.
PMID: 38382574
Gram-negative bacteria possess an asymmetric outer membrane (OM) primarily composed of lipopolysaccharides (LPS) on the outer leaflet and phospholipids on the inner leaflet. The outer membrane functions as an effective...
8.
Yekefallah M, van Aalst E, A M van Beekveld R, Eason I, Breukink E, Weingarth M, et al.
J Am Chem Soc
. 2024 Feb;
146(7):4421-4432.
PMID: 38334076
Lipids adhere to membrane proteins to stimulate or suppress molecular and ionic transport and signal transduction. Yet, the molecular details of lipid-protein interaction and their functional impact are poorly characterized....
9.
Wang X, Xu Y, Martin N, Breukink E
Biochim Biophys Acta Biomembr
. 2024 Jan;
1866(3):184282.
PMID: 38218577
Epilancin 15X is a lantibiotic that has an antimicrobial activity in the nanomolar concentration range towards Staphylococcus simulans. Such low MICs usually imply that these peptides employ a mechanism of...
10.
Xie M, Koch E, van Walree C, Sobota A, Sonnen A, Breukink E, et al.
Biophys J
. 2023 Oct;
122(23):4503-4517.
PMID: 37905401
Lipid oxidation is a universal degradative process of cell membrane lipids that is induced by oxidative stress and reactive oxygen and nitrogen species (RONS) in multiple pathophysiological situations. It has...