Edwin S Iversen
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Explore the profile of Edwin S Iversen including associated specialties, affiliations and a list of published articles.
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85
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4112
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Recent Articles
1.
Huang H, Hu C, Na J, Hart S, Gnanaolivu R, Abozaid M, et al.
Nature
. 2025 Jan;
638(8050):528-537.
PMID: 39779857
Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers. However, variants of uncertain significance limit the clinical utility of test results. Thus,...
2.
Nepomuceno T, Lyra P, Zhu J, Yi F, Martin R, Lupu D, et al.
JCO Clin Cancer Inform
. 2024 May;
8:e2300251.
PMID: 38709234
Purpose: The emergence of large real-world clinical databases and tools to mine electronic medical records has allowed for an unprecedented look at large data sets with clinical and epidemiologic correlates....
3.
Lyra Jr P, Nepomuceno T, de Souza M, Machado G, Veloso M, Henriques T, et al.
Genet Med
. 2020 Oct;
23(2):306-315.
PMID: 33087888
Purpose: BRCA1 pathogenic variant heterozygotes are at a substantially increased risk for breast and ovarian cancer. The widespread uptake of testing has led to a significant increase in the detection...
4.
Bakovic M, Thakkar D, DeBenedittis P, Chong D, Thomas M, Iversen E, et al.
J Vis Exp
. 2020 Sep;
(162).
PMID: 32894270
By replacing lost or dysfunctional myocardium, tissue regeneration is a promising approach to treat heart failure. However, the challenge of detecting bona fide heart regeneration limits the validation of potential...
5.
Trabert B, Tworoger S, OBrien K, Townsend M, Fortner R, Iversen E, et al.
Cancer Res
. 2020 Jan;
80(5):1210-1218.
PMID: 31932455
Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address...
6.
Reid B, Permuth J, Chen Y, Fridley B, Iversen E, Chen Z, et al.
Cancer Epidemiol Biomarkers Prev
. 2019 Apr;
28(7):1117-1126.
PMID: 30948450
Background: Germline DNA copy number variation (CNV) is a ubiquitous source of genetic variation and remains largely unexplored in association with epithelial ovarian cancer (EOC) risk. Methods: CNV was quantified...
7.
Fernandes V, Golubeva V, Di Pietro G, Shields C, Amankwah K, Nepomuceno T, et al.
J Biol Chem
. 2019 Feb;
294(15):5980-5992.
PMID: 30765603
Genetic testing for , a DNA repair protein, can identify carriers of pathogenic variants associated with a substantially increased risk for breast and ovarian cancers. However, an association with increased...
8.
Iversen E, McCarthy J, Burdett K, Lipton G, Phillips G, Dressman H, et al.
Int J Radiat Biol
. 2018 Oct;
96(1):47-56.
PMID: 30371121
Design and characterization of a radiation biodosimetry device are complicated by the fact that the requisite data are not available in the intended use population, namely humans exposed to a...
9.
Kelemen L, Earp M, Fridley B, Chenevix-Trench G, Fasching P, Beckmann M, et al.
Int J Mol Sci
. 2018 Aug;
19(9).
PMID: 30134598
Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We...
10.
Earp M, Tyrer J, Winham S, Lin H, Chornokur G, Dennis J, et al.
PLoS One
. 2018 Jul;
13(7):e0197561.
PMID: 29979793
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily...