Edwin J Vazquez-Cintron
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Explore the profile of Edwin J Vazquez-Cintron including associated specialties, affiliations and a list of published articles.
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9
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99
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Recent Articles
1.
Machamer J, Vazquez-Cintron E, Stenslik M, Pagarigan K, Bradford A, Ondeck C, et al.
Front Cell Neurosci
. 2023 Aug;
17:1226194.
PMID: 37650071
Introduction: Botulinum neurotoxin (BoNT) causes neuroparalytic disease and death by blocking neuromuscular transmission. There are no specific therapies for clinical botulism and the only treatment option is supportive care until...
2.
Dyer R, Isoda H, Salcedo G, Speciale G, Fletcher M, Le L, et al.
Sci Rep
. 2022 Jun;
12(1):9956.
PMID: 35705606
The botulinum neurotoxin serotype A (BoNT/A) cuts a single peptide bond in SNAP25, an activity used to treat a wide range of diseases. Reengineering the substrate specificity of BoNT/A's protease...
3.
Machamer J, Vazquez-Cintron E, OBrien S, Kelly K, Altvater A, Pagarigan K, et al.
Mol Med
. 2022 Jun;
28(1):61.
PMID: 35659174
Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis and death by asphyxiation. Other than post-exposure prophylaxis with antitoxin,...
4.
Navratilova E, Oyarzo J, Anderson T, Broide R, Subramaniam S, Vazquez-Cintron E, et al.
Cephalalgia
. 2022 May;
42(11-12):1194-1206.
PMID: 35546268
Objective: Investigation of onabotulinumtoxinA in a murine model of acute and persistent post-traumatic headache. Methods: Mild traumatic brain injury was induced with a weight drop method. Periorbital and hindpaw cutaneous...
5.
McNutt P, Vazquez-Cintron E, Tenezaca L, Ondeck C, Kelly K, Mangkhalakhili M, et al.
Sci Transl Med
. 2021 Jan;
13(575).
PMID: 33408188
Botulism is caused by a potent neurotoxin that blocks neuromuscular transmission, resulting in death by asphyxiation. Currently, the therapeutic options are limited and there is no antidote. Here, we harness...
6.
Vazquez-Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al.
Sci Rep
. 2017 Feb;
7:42923.
PMID: 28220863
Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to...
7.
Vazquez-Cintron E, Vakulenko M, Band P, Stanker L, Johnson E, Ichtchenko K
PLoS One
. 2014 Jan;
9(1):e85517.
PMID: 24465585
We have previously described genetic constructs and expression systems that enable facile production of recombinant derivatives of botulinum neurotoxins (BoNTs) that retain the structural and trafficking properties of wt BoNTs....
8.
Vazquez-Cintron E, Monu N, Burns J, Blum R, Chen G, Lopez P, et al.
PLoS One
. 2012 May;
7(5):e36101.
PMID: 22567129
CD8(+) tumor infiltrating T cells (TIL) lack effector-phase functions due to defective proximal TCR-mediated signaling previously shown to result from inactivation of p56(lck) kinase. We identify a novel interacting partner...
9.
Vazquez-Cintron E, Monu N, Frey A
J Immunol
. 2010 Dec;
185(12):7133-40.
PMID: 21127315
The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8(+) T cells proves that tumors express Ags capable of eliciting immune response. Therefore, in general, tumor escape from immune-mediated...