Tumor-induced Disruption of Proximal TCR-mediated Signal Transduction in Tumor-infiltrating CD8+ Lymphocytes Inactivates Antitumor Effector Phase

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2010 Dec 4

PMID 21127315

Citations 26

Authors

Edwin J Vazquez-Cintron

Ngozi R Monu

Alan B Frey

Affiliations

Soon will be listed here.

Abstract

The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8(+) T cells proves that tumors express Ags capable of eliciting immune response. Therefore, in general, tumor escape from immune-mediated clearance is not attributable to immunological ignorance. However, tumor-infiltrating lymphocytes are defective in effector phase function, demonstrating tumor-induced immune suppression that likely underlies tumor escape. Since exocytosis of lytic granules is dependent upon TCR-mediated signal transduction, it is a reasonable contention that tumors may induce defective signal transduction in tumor infiltrating T cells. In this review, we consider the biochemical basis for antitumor T cell dysfunction, focusing on the role of inhibitory signaling receptors in restricting TCR-mediated signaling in tumor-infiltrating lymphocytes.

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