Edwin Antony
Overview
Explore the profile of Edwin Antony including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
1092
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Recent Articles
1.
Roshan P, Kaushik V, Mistry A, Vayyeti A, Antony A, Luebbers R, et al.
bioRxiv
. 2025 Jan;
PMID: 39868089
Replication protein A (RPA) is a heterotrimeric single-strand DNA binding protein that is integral to DNA metabolism. Segregation of RPA functions in response to DNA damage is fine-tuned by hyperphosphorylation...
2.
Deveryshetty J, Mistry A, Pangeni S, Ghoneim M, Tokmina-Lukaszewska M, Kaushik V, et al.
bioRxiv
. 2024 Nov;
PMID: 39574592
Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs). The DSBs are resected to yield single-stranded DNA (ssDNA) that are coated by Replication Protein A (RPA). Rad51 is a recombinase and...
3.
Granger S, Sharma R, Kaushik V, Razzaghi M, Honda M, Gaur P, et al.
Nucleic Acids Res
. 2024 Sep;
52(20):12422-12437.
PMID: 39329264
Human replication protein A (RPA) is a heterotrimeric ssDNA binding protein responsible for many aspects of cellular DNA metabolism. Dynamic interactions of the four RPA DNA binding domains (DBDs) with...
4.
Chadda R, Kaushik V, Ahmad I, Deveryshetty J, Holehouse A, Sigurdsson S, et al.
Nucleic Acids Res
. 2024 Jul;
52(19):11626-11640.
PMID: 38989614
Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper to direct the ssDNA...
5.
Norris J, Rogers L, Pytko K, Dannenberg R, Perreault S, Kaushik V, et al.
Nucleic Acids Res
. 2024 Jun;
52(13):7650-7664.
PMID: 38842913
DNA polymerase δ (pol δ) holoenzymes, comprised of pol δ and the processivity sliding clamp, PCNA, carry out DNA synthesis during lagging strand replication, initiation of leading strand replication, and...
6.
7.
Chadda R, Kaushik V, Ahmad I, Deveryshetty J, Holehouse A, Sigurdsson S, et al.
bioRxiv
. 2024 Apr;
PMID: 38585962
Single-stranded DNA (ssDNA) intermediates, which emerge during DNA metabolic processes are shielded by Replication Protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper, directing the ssDNA towards...
8.
Kuppa S, Corless E, Caldwell C, Spies M, Antony E
Methods
. 2024 Feb;
224:47-53.
PMID: 38387709
Nucleotide excision repair (NER) promotes genomic integrity by removing bulky DNA adducts introduced by external factors such as ultraviolet light. Defects in NER enzymes are associated with pathological conditions such...
9.
Pangeni S, Biswas G, Kaushik V, Kuppa S, Yang O, Lin C, et al.
J Mol Biol
. 2024 Feb;
436(6):168491.
PMID: 38360091
Replication Protein A (RPA) is asingle strandedDNA(ssDNA)binding protein that coordinates diverse DNA metabolic processes including DNA replication, repair, and recombination. RPA is a heterotrimeric protein with six functional oligosaccharide/oligonucleotide (OB)...
10.
Kaushik V, Chadda R, Kuppa S, Pokhrel N, Vayyeti A, Grady S, et al.
Methods
. 2024 Feb;
223:95-105.
PMID: 38301751
DNA metabolic processes including replication, repair, recombination, and telomere maintenance occur on single-stranded DNA (ssDNA). In each of these complex processes, dozens of proteins function together on the ssDNA template....